aceK protein (Burkholderia cenocepacia) - STRING interaction network

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aceK

Isocitrate dehydrogenase kinase/phosphatase family protein; Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation. (608 aa)

Predicted Functional Partners:

icd

0.979

aceA

0.806

DM40_4470

0.752

DM40_527

0.626

aceB

0.491

DM40_510

0.489

DM40_2919

0.447

DM40_525

0.445

DM40_529

0.434

putA

0.422

Your Current Organism:

Burkholderia cenocepacia

NCBI taxonomy Id: 95486
Other names: ATCC BAA-245, ATCC:BAA:245, B. cenocepacia, Burkholderia cenocepacia Vandamme et al. 2003, Burkholderia cepacia genomovar III, Burkholderia cepacia genomovar IIIb, CCM 4899, CCUG 48434, DSM 16553, LMG 16656, LMG:16656, NCTC 13227

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DM40_2919	aceK	DM40_2919	DM40_526	RDD family protein.	Isocitrate dehydrogenase kinase/phosphatase family protein; Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.	0.447
DM40_4470	aceA	DM40_4470	DM40_2684	Isocitrate lyase.	Isocit_lyase: isocitrate lyase.	0.948
DM40_4470	aceB	DM40_4470	DM40_2688	Isocitrate lyase.	malate_syn_A: malate synthase A; Belongs to the malate synthase family.	0.997
DM40_4470	aceK	DM40_4470	DM40_526	Isocitrate lyase.	Isocitrate dehydrogenase kinase/phosphatase family protein; Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.	0.752
DM40_510	aceK	DM40_510	DM40_526	Hypothetical protein.	Isocitrate dehydrogenase kinase/phosphatase family protein; Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.	0.489
DM40_525	aceK	DM40_525	DM40_526	Metallo-beta-lactamase superfamily protein.	Isocitrate dehydrogenase kinase/phosphatase family protein; Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.	0.445
DM40_527	DM40_529	DM40_527	DM40_529	Carbonic anhydrase family protein.	Putative protein YchJ.	0.434
DM40_527	aceK	DM40_527	DM40_526	Carbonic anhydrase family protein.	Isocitrate dehydrogenase kinase/phosphatase family protein; Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.	0.626
DM40_529	DM40_527	DM40_529	DM40_527	Putative protein YchJ.	Carbonic anhydrase family protein.	0.434
DM40_529	aceK	DM40_529	DM40_526	Putative protein YchJ.	Isocitrate dehydrogenase kinase/phosphatase family protein; Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.	0.434
aceA	DM40_4470	DM40_2684	DM40_4470	Isocit_lyase: isocitrate lyase.	Isocitrate lyase.	0.948
aceA	aceB	DM40_2684	DM40_2688	Isocit_lyase: isocitrate lyase.	malate_syn_A: malate synthase A; Belongs to the malate synthase family.	0.999
aceA	aceK	DM40_2684	DM40_526	Isocit_lyase: isocitrate lyase.	Isocitrate dehydrogenase kinase/phosphatase family protein; Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.	0.806
aceB	DM40_4470	DM40_2688	DM40_4470	malate_syn_A: malate synthase A; Belongs to the malate synthase family.	Isocitrate lyase.	0.997
aceB	aceA	DM40_2688	DM40_2684	malate_syn_A: malate synthase A; Belongs to the malate synthase family.	Isocit_lyase: isocitrate lyase.	0.999
aceB	aceK	DM40_2688	DM40_526	malate_syn_A: malate synthase A; Belongs to the malate synthase family.	Isocitrate dehydrogenase kinase/phosphatase family protein; Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.	0.491
aceB	icd	DM40_2688	DM40_160	malate_syn_A: malate synthase A; Belongs to the malate synthase family.	Prok_nadp_idh: isocitrate dehydrogenase, NADP-dependent.	0.578
aceK	DM40_2919	DM40_526	DM40_2919	Isocitrate dehydrogenase kinase/phosphatase family protein; Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.	RDD family protein.	0.447
aceK	DM40_4470	DM40_526	DM40_4470	Isocitrate dehydrogenase kinase/phosphatase family protein; Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.	Isocitrate lyase.	0.752
aceK	DM40_510	DM40_526	DM40_510	Isocitrate dehydrogenase kinase/phosphatase family protein; Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.	Hypothetical protein.	0.489

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