| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CHD7 | CHD8 | ENSPANP00000000025 | ENSPANP00000014621 | Chromodomain helicase DNA binding protein 7. | Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] | 0.947 |
| CHD7 | CHD9 | ENSPANP00000000025 | ENSPANP00000012697 | Chromodomain helicase DNA binding protein 7. | Chromodomain helicase DNA binding protein 9. | 0.874 |
| CHD7 | CTNNB1 | ENSPANP00000000025 | ENSPANP00000004867 | Chromodomain helicase DNA binding protein 7. | Catenin beta 1. | 0.755 |
| CHD7 | KIF7 | ENSPANP00000000025 | ENSPANP00000014443 | Chromodomain helicase DNA binding protein 7. | Kinesin family member 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | 0.672 |
| CHD7 | LTBP2 | ENSPANP00000000025 | ENSPANP00000004369 | Chromodomain helicase DNA binding protein 7. | Latent transforming growth factor beta binding protein 2. | 0.689 |
| CHD7 | RBM20 | ENSPANP00000000025 | ENSPANP00000023394 | Chromodomain helicase DNA binding protein 7. | RNA binding motif protein 20. | 0.665 |
| CHD7 | RTF1 | ENSPANP00000000025 | ENSPANP00000016400 | Chromodomain helicase DNA binding protein 7. | RTF1 homolog, Paf1/RNA polymerase II complex component. | 0.665 |
| CHD7 | SMARCA4 | ENSPANP00000000025 | ENSPANP00000037200 | Chromodomain helicase DNA binding protein 7. | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4. | 0.694 |
| CHD7 | SMARCC2 | ENSPANP00000000025 | ENSPANP00000046639 | Chromodomain helicase DNA binding protein 7. | SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2. | 0.706 |
| CHD7 | SSRP1 | ENSPANP00000000025 | ENSPANP00000023422 | Chromodomain helicase DNA binding protein 7. | FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] | 0.667 |
| CHD8 | CHD7 | ENSPANP00000014621 | ENSPANP00000000025 | Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] | Chromodomain helicase DNA binding protein 7. | 0.947 |
| CHD8 | CHD9 | ENSPANP00000014621 | ENSPANP00000012697 | Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] | Chromodomain helicase DNA binding protein 9. | 0.875 |
| CHD8 | CTNNB1 | ENSPANP00000014621 | ENSPANP00000004867 | Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] | Catenin beta 1. | 0.998 |
| CHD8 | RTF1 | ENSPANP00000014621 | ENSPANP00000016400 | Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] | RTF1 homolog, Paf1/RNA polymerase II complex component. | 0.688 |
| CHD8 | SMARCA4 | ENSPANP00000014621 | ENSPANP00000037200 | Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4. | 0.401 |
| CHD8 | SMARCC2 | ENSPANP00000014621 | ENSPANP00000046639 | Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] | SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2. | 0.421 |
| CHD8 | SSRP1 | ENSPANP00000014621 | ENSPANP00000023422 | Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] | FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] | 0.667 |
| CHD9 | CHD7 | ENSPANP00000012697 | ENSPANP00000000025 | Chromodomain helicase DNA binding protein 9. | Chromodomain helicase DNA binding protein 7. | 0.874 |
| CHD9 | CHD8 | ENSPANP00000012697 | ENSPANP00000014621 | Chromodomain helicase DNA binding protein 9. | Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] | 0.875 |
| CHD9 | CTNNB1 | ENSPANP00000012697 | ENSPANP00000004867 | Chromodomain helicase DNA binding protein 9. | Catenin beta 1. | 0.745 |
