Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ITKTyrosine-protein kinase. (620 aa)    
Predicted Functional Partners:
LCP2
Lymphocyte cytosolic protein 2.
   
 0.997
PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.
   
0.988
VAV1
Vav guanine nucleotide exchange factor 1.
   
 0.971
HCK
Tyrosine-protein kinase.
  
0.965
TXK
Tyrosine-protein kinase.
  
 
0.962
TEC
Tyrosine-protein kinase.
  
 
 
0.957
VAV3
Vav guanine nucleotide exchange factor 3.
   
 0.953
CD247
Uncharacterized protein.
   
 0.952
VAV2
Vav guanine nucleotide exchange factor 2.
   
 0.951
LYN
Tyrosine-protein kinase.
  
 
0.944
Your Current Organism:
Papio anubis
NCBI taxonomy Id: 9555
Other names: Anubis baboon, Doguera baboon, Kenya baboon, P. anubis, Papio cynocephalus anubis, Papio doguera, Papio hamadryas anubis, Papio hamadryas doguera, baboon, olive baboon
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