| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BDNF | IGF1R | ENSPANP00000043496 | ENSPANP00000036663 | Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. | Tyrosine-protein kinase receptor. | 0.746 |
| BDNF | MET | ENSPANP00000043496 | ENSPANP00000030652 | Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. | Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] | 0.694 |
| BDNF | NGFR | ENSPANP00000043496 | ENSPANP00000040193 | Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. | Nerve growth factor receptor. | 0.970 |
| BDNF | NTF3 | ENSPANP00000043496 | ENSPANP00000003531 | Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. | Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. | 0.844 |
| BDNF | NTRK1 | ENSPANP00000043496 | ENSPANP00000002522 | Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. | Tyrosine-protein kinase receptor. | 0.980 |
| BDNF | NTRK2 | ENSPANP00000043496 | ENSPANP00000035132 | Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. | Tyrosine-protein kinase receptor. | 0.998 |
| BDNF | NTRK3 | ENSPANP00000043496 | ENSPANP00000029827 | Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. | Tyrosine-protein kinase receptor. | 0.927 |
| BDNF | PDGFRA | ENSPANP00000043496 | ENSPANP00000007029 | Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. | Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. | 0.762 |
| BDNF | RET | ENSPANP00000043496 | ENSPANP00000020151 | Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. | Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. | 0.719 |
| BDNF | SORT1 | ENSPANP00000043496 | ENSPANP00000022813 | Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. | Sortilin. | 0.909 |
| IGF1R | BDNF | ENSPANP00000036663 | ENSPANP00000043496 | Tyrosine-protein kinase receptor. | Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. | 0.746 |
| IGF1R | NTF3 | ENSPANP00000036663 | ENSPANP00000003531 | Tyrosine-protein kinase receptor. | Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. | 0.675 |
| MET | BDNF | ENSPANP00000030652 | ENSPANP00000043496 | Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] | Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. | 0.694 |
| MET | NTF3 | ENSPANP00000030652 | ENSPANP00000003531 | Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] | Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. | 0.685 |
| NGFR | BDNF | ENSPANP00000040193 | ENSPANP00000043496 | Nerve growth factor receptor. | Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. | 0.970 |
| NGFR | NTF3 | ENSPANP00000040193 | ENSPANP00000003531 | Nerve growth factor receptor. | Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. | 0.990 |
| NGFR | NTRK1 | ENSPANP00000040193 | ENSPANP00000002522 | Nerve growth factor receptor. | Tyrosine-protein kinase receptor. | 0.946 |
| NGFR | NTRK2 | ENSPANP00000040193 | ENSPANP00000035132 | Nerve growth factor receptor. | Tyrosine-protein kinase receptor. | 0.902 |
| NGFR | NTRK3 | ENSPANP00000040193 | ENSPANP00000029827 | Nerve growth factor receptor. | Tyrosine-protein kinase receptor. | 0.898 |
| NGFR | SORT1 | ENSPANP00000040193 | ENSPANP00000022813 | Nerve growth factor receptor. | Sortilin. | 0.991 |
