| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CRHR1 | OPRM1 | ENSPANP00000040288 | ENSPANP00000029957 | Corticotropin releasing hormone receptor 1; Belongs to the G-protein coupled receptor 2 family. | Opioid receptor mu 1; Belongs to the G-protein coupled receptor 1 family. | 0.449 |
| CRHR1 | POMC | ENSPANP00000040288 | ENSPANP00000008204 | Corticotropin releasing hormone receptor 1; Belongs to the G-protein coupled receptor 2 family. | Proopiomelanocortin. | 0.971 |
| MC4R | MRAP | ENSPANP00000000220 | ENSPANP00000015546 | Melanocortin 4 receptor. | Melanocortin 2 receptor accessory protein. | 0.639 |
| MC4R | PCSK1 | ENSPANP00000000220 | ENSPANP00000001677 | Melanocortin 4 receptor. | Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family. | 0.687 |
| MC4R | POMC | ENSPANP00000000220 | ENSPANP00000008204 | Melanocortin 4 receptor. | Proopiomelanocortin. | 0.998 |
| MRAP | MC4R | ENSPANP00000015546 | ENSPANP00000000220 | Melanocortin 2 receptor accessory protein. | Melanocortin 4 receptor. | 0.639 |
| MRAP | POMC | ENSPANP00000015546 | ENSPANP00000008204 | Melanocortin 2 receptor accessory protein. | Proopiomelanocortin. | 0.988 |
| OPRD1 | OPRK1 | ENSPANP00000011500 | ENSPANP00000007541 | Opioid receptor delta 1; Belongs to the G-protein coupled receptor 1 family. | Opioid receptor kappa 1; Belongs to the G-protein coupled receptor 1 family. | 0.946 |
| OPRD1 | OPRL1 | ENSPANP00000011500 | ENSPANP00000029478 | Opioid receptor delta 1; Belongs to the G-protein coupled receptor 1 family. | Opioid related nociceptin receptor 1; Belongs to the G-protein coupled receptor 1 family. | 0.938 |
| OPRD1 | OPRM1 | ENSPANP00000011500 | ENSPANP00000029957 | Opioid receptor delta 1; Belongs to the G-protein coupled receptor 1 family. | Opioid receptor mu 1; Belongs to the G-protein coupled receptor 1 family. | 0.984 |
| OPRD1 | PDYN | ENSPANP00000011500 | ENSPANP00000016941 | Opioid receptor delta 1; Belongs to the G-protein coupled receptor 1 family. | Prodynorphin. | 0.981 |
| OPRD1 | PENK | ENSPANP00000011500 | ENSPANP00000008382 | Opioid receptor delta 1; Belongs to the G-protein coupled receptor 1 family. | Proenkephalin. | 0.994 |
| OPRD1 | POMC | ENSPANP00000011500 | ENSPANP00000008204 | Opioid receptor delta 1; Belongs to the G-protein coupled receptor 1 family. | Proopiomelanocortin. | 0.992 |
| OPRK1 | OPRD1 | ENSPANP00000007541 | ENSPANP00000011500 | Opioid receptor kappa 1; Belongs to the G-protein coupled receptor 1 family. | Opioid receptor delta 1; Belongs to the G-protein coupled receptor 1 family. | 0.946 |
| OPRK1 | OPRL1 | ENSPANP00000007541 | ENSPANP00000029478 | Opioid receptor kappa 1; Belongs to the G-protein coupled receptor 1 family. | Opioid related nociceptin receptor 1; Belongs to the G-protein coupled receptor 1 family. | 0.941 |
| OPRK1 | OPRM1 | ENSPANP00000007541 | ENSPANP00000029957 | Opioid receptor kappa 1; Belongs to the G-protein coupled receptor 1 family. | Opioid receptor mu 1; Belongs to the G-protein coupled receptor 1 family. | 0.944 |
| OPRK1 | PDYN | ENSPANP00000007541 | ENSPANP00000016941 | Opioid receptor kappa 1; Belongs to the G-protein coupled receptor 1 family. | Prodynorphin. | 0.969 |
| OPRK1 | PENK | ENSPANP00000007541 | ENSPANP00000008382 | Opioid receptor kappa 1; Belongs to the G-protein coupled receptor 1 family. | Proenkephalin. | 0.971 |
| OPRK1 | POMC | ENSPANP00000007541 | ENSPANP00000008204 | Opioid receptor kappa 1; Belongs to the G-protein coupled receptor 1 family. | Proopiomelanocortin. | 0.969 |
| OPRL1 | OPRD1 | ENSPANP00000029478 | ENSPANP00000011500 | Opioid related nociceptin receptor 1; Belongs to the G-protein coupled receptor 1 family. | Opioid receptor delta 1; Belongs to the G-protein coupled receptor 1 family. | 0.938 |
