| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADAM17 | TNF | ENSPANP00000012911 | ENSPANP00000011146 | ADAM metallopeptidase domain 17. | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] | 0.945 |
| ADAM17 | TNFRSF1A | ENSPANP00000012911 | ENSPANP00000008611 | ADAM metallopeptidase domain 17. | TNF receptor superfamily member 1A. | 0.460 |
| ADAM17 | TNFRSF1B | ENSPANP00000012911 | ENSPANP00000008807 | ADAM metallopeptidase domain 17. | TNF receptor superfamily member 1B. | 0.766 |
| DAB2IP | TNFRSF1B | ENSPANP00000028559 | ENSPANP00000008807 | DAB2 interacting protein. | TNF receptor superfamily member 1B. | 0.900 |
| DAB2IP | TRAF1 | ENSPANP00000028559 | ENSPANP00000018929 | DAB2 interacting protein. | TNF receptor-associated factor. | 0.698 |
| DAB2IP | TRAF2 | ENSPANP00000028559 | ENSPANP00000015727 | DAB2 interacting protein. | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. | 0.977 |
| DAXX | TNFRSF1A | ENSPANP00000012430 | ENSPANP00000008611 | Death domain associated protein. | TNF receptor superfamily member 1A. | 0.913 |
| DAXX | TNFRSF1B | ENSPANP00000012430 | ENSPANP00000008807 | Death domain associated protein. | TNF receptor superfamily member 1B. | 0.900 |
| LTA | TNF | ENSPANP00000015631 | ENSPANP00000011146 | Lymphotoxin alpha; Belongs to the tumor necrosis factor family. | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] | 0.618 |
| LTA | TNFRSF1A | ENSPANP00000015631 | ENSPANP00000008611 | Lymphotoxin alpha; Belongs to the tumor necrosis factor family. | TNF receptor superfamily member 1A. | 0.985 |
| LTA | TNFRSF1B | ENSPANP00000015631 | ENSPANP00000008807 | Lymphotoxin alpha; Belongs to the tumor necrosis factor family. | TNF receptor superfamily member 1B. | 0.946 |
| LTA | TRAF1 | ENSPANP00000015631 | ENSPANP00000018929 | Lymphotoxin alpha; Belongs to the tumor necrosis factor family. | TNF receptor-associated factor. | 0.479 |
| LTA | TRAF2 | ENSPANP00000015631 | ENSPANP00000015727 | Lymphotoxin alpha; Belongs to the tumor necrosis factor family. | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. | 0.509 |
| LTA | TRAF3 | ENSPANP00000015631 | ENSPANP00000013259 | Lymphotoxin alpha; Belongs to the tumor necrosis factor family. | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. | 0.547 |
| TNF | ADAM17 | ENSPANP00000011146 | ENSPANP00000012911 | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] | ADAM metallopeptidase domain 17. | 0.945 |
| TNF | LTA | ENSPANP00000011146 | ENSPANP00000015631 | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] | Lymphotoxin alpha; Belongs to the tumor necrosis factor family. | 0.618 |
| TNF | TNFRSF1A | ENSPANP00000011146 | ENSPANP00000008611 | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] | TNF receptor superfamily member 1A. | 0.993 |
| TNF | TNFRSF1B | ENSPANP00000011146 | ENSPANP00000008807 | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] | TNF receptor superfamily member 1B. | 0.982 |
| TNF | TRADD | ENSPANP00000011146 | ENSPANP00000013058 | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] | TNFRSF1A associated via death domain. | 0.975 |
| TNF | TRAF1 | ENSPANP00000011146 | ENSPANP00000018929 | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] | TNF receptor-associated factor. | 0.931 |
