| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| GPR132 | P2RX7 | ENSPANP00000027093 | ENSPANP00000010339 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. | 0.402 |
| IL1B | P2RX7 | ENSPANP00000011447 | ENSPANP00000010339 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. | 0.458 |
| P2RX5 | P2RX7 | ENSPANP00000041124 | ENSPANP00000010339 | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. | 0.581 |
| P2RX5 | P2RY2 | ENSPANP00000041124 | ENSPANP00000007588 | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. | Purinergic receptor P2Y2; Belongs to the G-protein coupled receptor 1 family. | 0.463 |
| P2RX5 | P2RY4 | ENSPANP00000041124 | ENSPANP00000007925 | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. | Pyrimidinergic receptor P2Y4; Belongs to the G-protein coupled receptor 1 family. | 0.443 |
| P2RX5 | P2RY6 | ENSPANP00000041124 | ENSPANP00000010607 | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. | Pyrimidinergic receptor P2Y6. | 0.459 |
| P2RX7 | GPR132 | ENSPANP00000010339 | ENSPANP00000027093 | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. | 0.402 |
| P2RX7 | IL1B | ENSPANP00000010339 | ENSPANP00000011447 | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | 0.458 |
| P2RX7 | P2RX5 | ENSPANP00000010339 | ENSPANP00000041124 | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. | 0.581 |
| P2RX7 | P2RY2 | ENSPANP00000010339 | ENSPANP00000007588 | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. | Purinergic receptor P2Y2; Belongs to the G-protein coupled receptor 1 family. | 0.509 |
| P2RX7 | P2RY4 | ENSPANP00000010339 | ENSPANP00000007925 | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. | Pyrimidinergic receptor P2Y4; Belongs to the G-protein coupled receptor 1 family. | 0.457 |
| P2RX7 | P2RY6 | ENSPANP00000010339 | ENSPANP00000010607 | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. | Pyrimidinergic receptor P2Y6. | 0.457 |
| P2RX7 | PANX1 | ENSPANP00000010339 | ENSPANP00000004157 | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. | Pannexin; Structural component of the gap junctions and the hemichannels. | 0.892 |
| P2RY2 | P2RX5 | ENSPANP00000007588 | ENSPANP00000041124 | Purinergic receptor P2Y2; Belongs to the G-protein coupled receptor 1 family. | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. | 0.463 |
| P2RY2 | P2RX7 | ENSPANP00000007588 | ENSPANP00000010339 | Purinergic receptor P2Y2; Belongs to the G-protein coupled receptor 1 family. | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. | 0.509 |
| P2RY2 | P2RY6 | ENSPANP00000007588 | ENSPANP00000010607 | Purinergic receptor P2Y2; Belongs to the G-protein coupled receptor 1 family. | Pyrimidinergic receptor P2Y6. | 0.931 |
| P2RY2 | PANX1 | ENSPANP00000007588 | ENSPANP00000004157 | Purinergic receptor P2Y2; Belongs to the G-protein coupled receptor 1 family. | Pannexin; Structural component of the gap junctions and the hemichannels. | 0.448 |
| P2RY4 | P2RX5 | ENSPANP00000007925 | ENSPANP00000041124 | Pyrimidinergic receptor P2Y4; Belongs to the G-protein coupled receptor 1 family. | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. | 0.443 |
| P2RY4 | P2RX7 | ENSPANP00000007925 | ENSPANP00000010339 | Pyrimidinergic receptor P2Y4; Belongs to the G-protein coupled receptor 1 family. | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. | 0.457 |
| P2RY6 | P2RX5 | ENSPANP00000010607 | ENSPANP00000041124 | Pyrimidinergic receptor P2Y6. | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. | 0.459 |
