| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BRCA1 | ENSPANP00000022319 | ENSPANP00000027226 | ENSPANP00000022319 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | Uncharacterized protein. | 0.650 |
| BRCA1 | ENSPANP00000026710 | ENSPANP00000027226 | ENSPANP00000026710 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | Rad60-SLD domain-containing protein. | 0.650 |
| BRCA1 | ENSPANP00000031745 | ENSPANP00000027226 | ENSPANP00000031745 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | Rad60-SLD domain-containing protein. | 0.619 |
| BRCA1 | ENSPANP00000044796 | ENSPANP00000027226 | ENSPANP00000044796 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | Small ubiquitin-related modifier. | 0.650 |
| BRCA1 | MITF | ENSPANP00000027226 | ENSPANP00000029888 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | Melanocyte inducing transcription factor. | 0.522 |
| BRCA1 | PIAS3 | ENSPANP00000027226 | ENSPANP00000027215 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | Protein inhibitor of activated STAT 3. | 0.798 |
| BRCA1 | RELA | ENSPANP00000027226 | ENSPANP00000044826 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | RELA proto-oncogene, NF-kB subunit. | 0.785 |
| BRCA1 | SUMO1 | ENSPANP00000027226 | ENSPANP00000041222 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | Ubiquitin-like domain-containing protein. | 0.650 |
| BRCA1 | UBE2I | ENSPANP00000027226 | ENSPANP00000031081 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. | 0.863 |
| ENSPANP00000022319 | BRCA1 | ENSPANP00000022319 | ENSPANP00000027226 | Uncharacterized protein. | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | 0.650 |
| ENSPANP00000022319 | MITF | ENSPANP00000022319 | ENSPANP00000029888 | Uncharacterized protein. | Melanocyte inducing transcription factor. | 0.777 |
| ENSPANP00000022319 | PIAS3 | ENSPANP00000022319 | ENSPANP00000027215 | Uncharacterized protein. | Protein inhibitor of activated STAT 3. | 0.861 |
| ENSPANP00000022319 | UBE2I | ENSPANP00000022319 | ENSPANP00000031081 | Uncharacterized protein. | Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. | 0.939 |
| ENSPANP00000026710 | BRCA1 | ENSPANP00000026710 | ENSPANP00000027226 | Rad60-SLD domain-containing protein. | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | 0.650 |
| ENSPANP00000026710 | MITF | ENSPANP00000026710 | ENSPANP00000029888 | Rad60-SLD domain-containing protein. | Melanocyte inducing transcription factor. | 0.777 |
| ENSPANP00000026710 | PIAS3 | ENSPANP00000026710 | ENSPANP00000027215 | Rad60-SLD domain-containing protein. | Protein inhibitor of activated STAT 3. | 0.861 |
| ENSPANP00000026710 | UBE2I | ENSPANP00000026710 | ENSPANP00000031081 | Rad60-SLD domain-containing protein. | Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. | 0.939 |
| ENSPANP00000031745 | BRCA1 | ENSPANP00000031745 | ENSPANP00000027226 | Rad60-SLD domain-containing protein. | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | 0.619 |
| ENSPANP00000031745 | MITF | ENSPANP00000031745 | ENSPANP00000029888 | Rad60-SLD domain-containing protein. | Melanocyte inducing transcription factor. | 0.761 |
| ENSPANP00000031745 | PIAS3 | ENSPANP00000031745 | ENSPANP00000027215 | Rad60-SLD domain-containing protein. | Protein inhibitor of activated STAT 3. | 0.852 |
