| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CD14 | TLR1 | ENSPANP00000030928 | ENSPANP00000000454 | CD14 molecule. | Toll-like receptor. | 0.486 |
| CD14 | TLR2 | ENSPANP00000030928 | ENSPANP00000010674 | CD14 molecule. | Toll-like receptor. | 0.983 |
| CD14 | TLR4 | ENSPANP00000030928 | ENSPANP00000029907 | CD14 molecule. | Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] | 0.974 |
| CD14 | TLR5 | ENSPANP00000030928 | ENSPANP00000014798 | CD14 molecule. | Toll-like receptor 5; Belongs to the Toll-like receptor family. | 0.424 |
| HMGB1 | MYD88 | ENSPANP00000006640 | ENSPANP00000015354 | High mobility group protein B1; Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functio [...] | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. | 0.422 |
| HMGB1 | NFKB1 | ENSPANP00000006640 | ENSPANP00000010853 | High mobility group protein B1; Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functio [...] | Nuclear factor kappa B subunit 1. | 0.441 |
| HMGB1 | TLR2 | ENSPANP00000006640 | ENSPANP00000010674 | High mobility group protein B1; Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functio [...] | Toll-like receptor. | 0.951 |
| HMGB1 | TLR4 | ENSPANP00000006640 | ENSPANP00000029907 | High mobility group protein B1; Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functio [...] | Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] | 0.991 |
| MYD88 | HMGB1 | ENSPANP00000015354 | ENSPANP00000006640 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. | High mobility group protein B1; Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functio [...] | 0.422 |
| MYD88 | NFKB1 | ENSPANP00000015354 | ENSPANP00000010853 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. | Nuclear factor kappa B subunit 1. | 0.855 |
| MYD88 | TICAM1 | ENSPANP00000015354 | ENSPANP00000006835 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. | Toll like receptor adaptor molecule 1. | 0.577 |
| MYD88 | TIRAP | ENSPANP00000015354 | ENSPANP00000042909 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. | TIR domain containing adaptor protein. | 0.996 |
| MYD88 | TLR1 | ENSPANP00000015354 | ENSPANP00000000454 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. | Toll-like receptor. | 0.987 |
| MYD88 | TLR2 | ENSPANP00000015354 | ENSPANP00000010674 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. | Toll-like receptor. | 0.992 |
| MYD88 | TLR4 | ENSPANP00000015354 | ENSPANP00000029907 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. | Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] | 0.996 |
| MYD88 | TLR5 | ENSPANP00000015354 | ENSPANP00000014798 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. | Toll-like receptor 5; Belongs to the Toll-like receptor family. | 0.990 |
| MYD88 | TOLLIP | ENSPANP00000015354 | ENSPANP00000002093 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. | Toll interacting protein. | 0.960 |
| NFKB1 | HMGB1 | ENSPANP00000010853 | ENSPANP00000006640 | Nuclear factor kappa B subunit 1. | High mobility group protein B1; Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functio [...] | 0.441 |
| NFKB1 | MYD88 | ENSPANP00000010853 | ENSPANP00000015354 | Nuclear factor kappa B subunit 1. | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. | 0.855 |
| NFKB1 | TLR1 | ENSPANP00000010853 | ENSPANP00000000454 | Nuclear factor kappa B subunit 1. | Toll-like receptor. | 0.432 |
