| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CDC45 | CDC6 | ENSPANP00000035423 | ENSPANP00000020590 | Cell division cycle 45. | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | 0.965 |
| CDC45 | CDT1 | ENSPANP00000035423 | ENSPANP00000001170 | Cell division cycle 45. | Chromatin licensing and DNA replication factor 1. | 0.974 |
| CDC45 | MCM2 | ENSPANP00000035423 | ENSPANP00000004650 | Cell division cycle 45. | DNA helicase; Belongs to the MCM family. | 0.997 |
| CDC45 | MCM3 | ENSPANP00000035423 | ENSPANP00000012989 | Cell division cycle 45. | DNA helicase; Belongs to the MCM family. | 0.988 |
| CDC45 | MCM4 | ENSPANP00000035423 | ENSPANP00000010964 | Cell division cycle 45. | DNA helicase; Belongs to the MCM family. | 0.996 |
| CDC45 | MCM5 | ENSPANP00000035423 | ENSPANP00000013225 | Cell division cycle 45. | DNA helicase; Belongs to the MCM family. | 0.995 |
| CDC45 | MCM6 | ENSPANP00000035423 | ENSPANP00000018042 | Cell division cycle 45. | DNA helicase; Belongs to the MCM family. | 0.996 |
| CDC45 | MCM7 | ENSPANP00000035423 | ENSPANP00000009605 | Cell division cycle 45. | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | 0.996 |
| CDC45 | MCM9 | ENSPANP00000035423 | ENSPANP00000004507 | Cell division cycle 45. | Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. | 0.951 |
| CDC45 | ORC1 | ENSPANP00000035423 | ENSPANP00000000718 | Cell division cycle 45. | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. | 0.990 |
| CDC6 | CDC45 | ENSPANP00000020590 | ENSPANP00000035423 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | Cell division cycle 45. | 0.965 |
| CDC6 | CDT1 | ENSPANP00000020590 | ENSPANP00000001170 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | Chromatin licensing and DNA replication factor 1. | 0.999 |
| CDC6 | MCM2 | ENSPANP00000020590 | ENSPANP00000004650 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | DNA helicase; Belongs to the MCM family. | 0.994 |
| CDC6 | MCM3 | ENSPANP00000020590 | ENSPANP00000012989 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | DNA helicase; Belongs to the MCM family. | 0.997 |
| CDC6 | MCM4 | ENSPANP00000020590 | ENSPANP00000010964 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | DNA helicase; Belongs to the MCM family. | 0.994 |
| CDC6 | MCM5 | ENSPANP00000020590 | ENSPANP00000013225 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | DNA helicase; Belongs to the MCM family. | 0.994 |
| CDC6 | MCM6 | ENSPANP00000020590 | ENSPANP00000018042 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | DNA helicase; Belongs to the MCM family. | 0.992 |
| CDC6 | MCM7 | ENSPANP00000020590 | ENSPANP00000009605 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | 0.997 |
| CDC6 | MCM9 | ENSPANP00000020590 | ENSPANP00000004507 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. | 0.965 |
| CDC6 | ORC1 | ENSPANP00000020590 | ENSPANP00000000718 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. | 0.997 |
