STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PYCARDPYD and CARD domain containing. (195 aa)    
Predicted Functional Partners:
NLRP3
NLR family pyrin domain containing 3.
   
 0.998
CASP1
Caspase 1; Belongs to the peptidase C14A family.
   
 0.997
NLRP12
Uncharacterized protein.
   
 0.996
IL18
Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.
   
 
 0.996
AIM2
Absent in melanoma 2.
    
 0.993
MEFV
MEFV innate immuity regulator, pyrin.
    
 0.981
CASP8
Caspase 8; Belongs to the peptidase C14A family.
   
 0.970
NLRP6
NLR family pyrin domain containing 6.
   
 0.967
NLRP7
NLR family pyrin domain containing 7.
   
 0.966
LOC101009375
Uncharacterized protein; Belongs to the peptidase C14A family.
   
 0.960
Your Current Organism:
Papio anubis
NCBI taxonomy Id: 9555
Other names: Anubis baboon, Doguera baboon, Kenya baboon, P. anubis, Papio cynocephalus anubis, Papio doguera, Papio hamadryas anubis, Papio hamadryas doguera, baboon, olive baboon
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.