| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AP4E1 | HYI | ENSPANP00000014041 | ENSPANP00000028210 | AP-4 complex subunit epsilon; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin- associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. | Putative hydroxypyruvate isomerase; Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde); Belongs to the hyi family. | 0.560 |
| AP4E1 | MRPS24 | ENSPANP00000014041 | ENSPANP00000018557 | AP-4 complex subunit epsilon; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin- associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. | Mitochondrial ribosomal protein S24. | 0.515 |
| AP4E1 | SPPL2A | ENSPANP00000014041 | ENSPANP00000014040 | AP-4 complex subunit epsilon; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin- associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. | Signal peptide peptidase like 2A. | 0.419 |
| HYI | AP4E1 | ENSPANP00000028210 | ENSPANP00000014041 | Putative hydroxypyruvate isomerase; Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde); Belongs to the hyi family. | AP-4 complex subunit epsilon; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin- associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. | 0.560 |
| HYI | MRPS24 | ENSPANP00000028210 | ENSPANP00000018557 | Putative hydroxypyruvate isomerase; Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde); Belongs to the hyi family. | Mitochondrial ribosomal protein S24. | 0.584 |
| HYI | SPPL2A | ENSPANP00000028210 | ENSPANP00000014040 | Putative hydroxypyruvate isomerase; Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde); Belongs to the hyi family. | Signal peptide peptidase like 2A. | 0.445 |
| MRPS24 | AP4E1 | ENSPANP00000018557 | ENSPANP00000014041 | Mitochondrial ribosomal protein S24. | AP-4 complex subunit epsilon; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin- associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. | 0.515 |
| MRPS24 | HYI | ENSPANP00000018557 | ENSPANP00000028210 | Mitochondrial ribosomal protein S24. | Putative hydroxypyruvate isomerase; Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde); Belongs to the hyi family. | 0.584 |
| MRPS24 | SPPL2A | ENSPANP00000018557 | ENSPANP00000014040 | Mitochondrial ribosomal protein S24. | Signal peptide peptidase like 2A. | 0.448 |
| SLC12A2 | SPPL2A | ENSPANP00000035147 | ENSPANP00000014040 | Solute carrier family 12 member 2. | Signal peptide peptidase like 2A. | 0.651 |
| SPPL2A | AP4E1 | ENSPANP00000014040 | ENSPANP00000014041 | Signal peptide peptidase like 2A. | AP-4 complex subunit epsilon; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin- associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. | 0.419 |
| SPPL2A | HYI | ENSPANP00000014040 | ENSPANP00000028210 | Signal peptide peptidase like 2A. | Putative hydroxypyruvate isomerase; Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde); Belongs to the hyi family. | 0.445 |
| SPPL2A | MRPS24 | ENSPANP00000014040 | ENSPANP00000018557 | Signal peptide peptidase like 2A. | Mitochondrial ribosomal protein S24. | 0.448 |
| SPPL2A | SLC12A2 | ENSPANP00000014040 | ENSPANP00000035147 | Signal peptide peptidase like 2A. | Solute carrier family 12 member 2. | 0.651 |
| SPPL2A | TNF | ENSPANP00000014040 | ENSPANP00000011146 | Signal peptide peptidase like 2A. | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] | 0.596 |
| SPPL2A | ZDHHC6 | ENSPANP00000014040 | ENSPANP00000021033 | Signal peptide peptidase like 2A. | Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. | 0.446 |
| TNF | SPPL2A | ENSPANP00000011146 | ENSPANP00000014040 | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] | Signal peptide peptidase like 2A. | 0.596 |
| ZDHHC6 | SPPL2A | ENSPANP00000021033 | ENSPANP00000014040 | Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. | Signal peptide peptidase like 2A. | 0.446 |
