| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| GINS4 | MCM2 | ENSPANP00000018584 | ENSPANP00000004650 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. | DNA helicase; Belongs to the MCM family. | 0.972 |
| GINS4 | MCM5 | ENSPANP00000018584 | ENSPANP00000013225 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. | DNA helicase; Belongs to the MCM family. | 0.956 |
| GINS4 | MCM7 | ENSPANP00000018584 | ENSPANP00000009605 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | 0.975 |
| GINS4 | PRIM1 | ENSPANP00000018584 | ENSPANP00000007747 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. | DNA primase; Belongs to the eukaryotic-type primase small subunit family. | 0.883 |
| GINS4 | RFC3 | ENSPANP00000018584 | ENSPANP00000004396 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. | Replication factor C subunit 3. | 0.530 |
| GINS4 | RPA1 | ENSPANP00000018584 | ENSPANP00000019489 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | 0.919 |
| GINS4 | TIMELESS | ENSPANP00000018584 | ENSPANP00000012256 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. | Timeless circadian regulator. | 0.882 |
| GINS4 | TIPIN | ENSPANP00000018584 | ENSPANP00000014157 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. | 0.889 |
| GINS4 | WDHD1 | ENSPANP00000018584 | ENSPANP00000016946 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. | WD repeat and HMG-box DNA binding protein 1. | 0.908 |
| MCM2 | GINS4 | ENSPANP00000004650 | ENSPANP00000018584 | DNA helicase; Belongs to the MCM family. | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. | 0.972 |
| MCM2 | MCM5 | ENSPANP00000004650 | ENSPANP00000013225 | DNA helicase; Belongs to the MCM family. | DNA helicase; Belongs to the MCM family. | 0.999 |
| MCM2 | MCM7 | ENSPANP00000004650 | ENSPANP00000009605 | DNA helicase; Belongs to the MCM family. | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | 0.999 |
| MCM2 | PRIM1 | ENSPANP00000004650 | ENSPANP00000007747 | DNA helicase; Belongs to the MCM family. | DNA primase; Belongs to the eukaryotic-type primase small subunit family. | 0.977 |
| MCM2 | RFC3 | ENSPANP00000004650 | ENSPANP00000004396 | DNA helicase; Belongs to the MCM family. | Replication factor C subunit 3. | 0.909 |
| MCM2 | RPA1 | ENSPANP00000004650 | ENSPANP00000019489 | DNA helicase; Belongs to the MCM family. | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | 0.938 |
| MCM2 | TIMELESS | ENSPANP00000004650 | ENSPANP00000012256 | DNA helicase; Belongs to the MCM family. | Timeless circadian regulator. | 0.933 |
| MCM2 | TIPIN | ENSPANP00000004650 | ENSPANP00000014157 | DNA helicase; Belongs to the MCM family. | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. | 0.886 |
| MCM2 | WDHD1 | ENSPANP00000004650 | ENSPANP00000016946 | DNA helicase; Belongs to the MCM family. | WD repeat and HMG-box DNA binding protein 1. | 0.981 |
| MCM5 | GINS4 | ENSPANP00000013225 | ENSPANP00000018584 | DNA helicase; Belongs to the MCM family. | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. | 0.956 |
| MCM5 | MCM2 | ENSPANP00000013225 | ENSPANP00000004650 | DNA helicase; Belongs to the MCM family. | DNA helicase; Belongs to the MCM family. | 0.999 |
