| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACVR1B | SMAD2 | ENSPANP00000015802 | ENSPANP00000037043 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. | Mothers against decapentaplegic homolog. | 0.990 |
| ACVR1B | SMAD3 | ENSPANP00000015802 | ENSPANP00000014165 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. | Mothers against decapentaplegic homolog. | 0.987 |
| ACVR1B | SMAD4 | ENSPANP00000015802 | ENSPANP00000006643 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. | Mothers against decapentaplegic homolog. | 0.808 |
| ACVR1B | SMAD7 | ENSPANP00000015802 | ENSPANP00000005066 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. | Mothers against decapentaplegic homolog. | 0.918 |
| ACVR1B | SMAD9 | ENSPANP00000015802 | ENSPANP00000031197 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. | Mothers against decapentaplegic homolog. | 0.631 |
| ACVR1B | SMURF2 | ENSPANP00000015802 | ENSPANP00000031635 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. | SMAD specific E3 ubiquitin protein ligase 2. | 0.816 |
| ACVR1B | TGFBR1 | ENSPANP00000015802 | ENSPANP00000046935 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. | 0.744 |
| FOXO3 | MAPK1 | ENSPANP00000004459 | ENSPANP00000025866 | Forkhead box O3. | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | 0.949 |
| FOXO3 | SMAD2 | ENSPANP00000004459 | ENSPANP00000037043 | Forkhead box O3. | Mothers against decapentaplegic homolog. | 0.976 |
| FOXO3 | SMAD3 | ENSPANP00000004459 | ENSPANP00000014165 | Forkhead box O3. | Mothers against decapentaplegic homolog. | 0.990 |
| FOXO3 | SMAD4 | ENSPANP00000004459 | ENSPANP00000006643 | Forkhead box O3. | Mothers against decapentaplegic homolog. | 0.869 |
| FOXO3 | SMAD9 | ENSPANP00000004459 | ENSPANP00000031197 | Forkhead box O3. | Mothers against decapentaplegic homolog. | 0.497 |
| LEMD3 | SMAD2 | ENSPANP00000002137 | ENSPANP00000037043 | LEM domain containing 3. | Mothers against decapentaplegic homolog. | 0.979 |
| LEMD3 | SMAD3 | ENSPANP00000002137 | ENSPANP00000014165 | LEM domain containing 3. | Mothers against decapentaplegic homolog. | 0.986 |
| LEMD3 | SMAD9 | ENSPANP00000002137 | ENSPANP00000031197 | LEM domain containing 3. | Mothers against decapentaplegic homolog. | 0.983 |
| MAPK1 | FOXO3 | ENSPANP00000025866 | ENSPANP00000004459 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | Forkhead box O3. | 0.949 |
| MAPK1 | SMAD2 | ENSPANP00000025866 | ENSPANP00000037043 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | Mothers against decapentaplegic homolog. | 0.982 |
| MAPK1 | SMAD3 | ENSPANP00000025866 | ENSPANP00000014165 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | Mothers against decapentaplegic homolog. | 0.989 |
| MAPK1 | SMAD4 | ENSPANP00000025866 | ENSPANP00000006643 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | Mothers against decapentaplegic homolog. | 0.637 |
| MAPK1 | SMAD9 | ENSPANP00000025866 | ENSPANP00000031197 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | Mothers against decapentaplegic homolog. | 0.949 |
