RTEL1 protein (Papio anubis) - STRING interaction network

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RTEL1

Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1355 aa)

Predicted Functional Partners:

SLF1

0.983

WRN

0.983

BRCA1

0.951

MLH1

0.945

TOPBP1

0.941

ERCC3

0.933

BARD1

0.931

GTF2H2

0.930

GTF2H1

0.929

GTF2H3

0.928

Your Current Organism:

Papio anubis

NCBI taxonomy Id: 9555
Other names: Anubis baboon, Doguera baboon, Kenya baboon, P. anubis, Papio cynocephalus anubis, Papio doguera, Papio hamadryas anubis, Papio hamadryas doguera, baboon, olive baboon

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BARD1	BRCA1	ENSPANP00000005319	ENSPANP00000027226	BRCA1 associated RING domain 1.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.999
BARD1	MLH1	ENSPANP00000005319	ENSPANP00000003232	BRCA1 associated RING domain 1.	MutL homolog 1.	0.643
BARD1	RTEL1	ENSPANP00000005319	ENSPANP00000047749	BRCA1 associated RING domain 1.	Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...]	0.931
BARD1	SLF1	ENSPANP00000005319	ENSPANP00000003676	BRCA1 associated RING domain 1.	SMC5-SMC6 complex localization factor 1.	0.995
BARD1	TOPBP1	ENSPANP00000005319	ENSPANP00000006180	BRCA1 associated RING domain 1.	DNA topoisomerase II binding protein 1.	0.971
BARD1	WRN	ENSPANP00000005319	ENSPANP00000018132	BRCA1 associated RING domain 1.	WRN RecQ like helicase.	0.991
BRCA1	BARD1	ENSPANP00000027226	ENSPANP00000005319	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	BRCA1 associated RING domain 1.	0.999
BRCA1	MLH1	ENSPANP00000027226	ENSPANP00000003232	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	MutL homolog 1.	0.920
BRCA1	RTEL1	ENSPANP00000027226	ENSPANP00000047749	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...]	0.951
BRCA1	SLF1	ENSPANP00000027226	ENSPANP00000003676	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	SMC5-SMC6 complex localization factor 1.	0.921
BRCA1	TOPBP1	ENSPANP00000027226	ENSPANP00000006180	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	DNA topoisomerase II binding protein 1.	0.977
BRCA1	WRN	ENSPANP00000027226	ENSPANP00000018132	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	WRN RecQ like helicase.	0.990
ERCC3	GTF2H1	ENSPANP00000014708	ENSPANP00000007277	ERCC excision repair 3, TFIIH core complex helicase subunit.	General transcription factor IIH subunit 1.	0.998
ERCC3	GTF2H2	ENSPANP00000014708	ENSPANP00000001026	ERCC excision repair 3, TFIIH core complex helicase subunit.	General transcription factor IIH subunit.	0.998
ERCC3	GTF2H3	ENSPANP00000014708	ENSPANP00000045977	ERCC excision repair 3, TFIIH core complex helicase subunit.	General transcription factor IIH subunit 3.	0.998
ERCC3	MLH1	ENSPANP00000014708	ENSPANP00000003232	ERCC excision repair 3, TFIIH core complex helicase subunit.	MutL homolog 1.	0.476
ERCC3	RTEL1	ENSPANP00000014708	ENSPANP00000047749	ERCC excision repair 3, TFIIH core complex helicase subunit.	Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...]	0.933
ERCC3	WRN	ENSPANP00000014708	ENSPANP00000018132	ERCC excision repair 3, TFIIH core complex helicase subunit.	WRN RecQ like helicase.	0.512
GTF2H1	ERCC3	ENSPANP00000007277	ENSPANP00000014708	General transcription factor IIH subunit 1.	ERCC excision repair 3, TFIIH core complex helicase subunit.	0.998
GTF2H1	GTF2H2	ENSPANP00000007277	ENSPANP00000001026	General transcription factor IIH subunit 1.	General transcription factor IIH subunit.	0.998

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