| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AKT1 | ESR1 | ENSPANP00000013336 | ENSPANP00000015224 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | 0.992 |
| AKT1 | ESR2 | ENSPANP00000013336 | ENSPANP00000017082 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Uncharacterized protein. | 0.968 |
| AKT1 | FOS | ENSPANP00000013336 | ENSPANP00000015872 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Fos proto-oncogene, AP-1 transcription factor subunit. | 0.473 |
| AKT1 | SRC | ENSPANP00000013336 | ENSPANP00000029342 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Tyrosine-protein kinase. | 0.927 |
| ESR1 | AKT1 | ENSPANP00000015224 | ENSPANP00000013336 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | 0.992 |
| ESR1 | ESR2 | ENSPANP00000015224 | ENSPANP00000017082 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Uncharacterized protein. | 0.999 |
| ESR1 | FOS | ENSPANP00000015224 | ENSPANP00000015872 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Fos proto-oncogene, AP-1 transcription factor subunit. | 0.990 |
| ESR1 | MED1 | ENSPANP00000015224 | ENSPANP00000020534 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | 0.996 |
| ESR1 | NCOA1 | ENSPANP00000015224 | ENSPANP00000043481 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Nuclear receptor coactivator. | 0.996 |
| ESR1 | NCOA2 | ENSPANP00000015224 | ENSPANP00000006814 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Nuclear receptor coactivator. | 0.994 |
| ESR1 | NCOA3 | ENSPANP00000015224 | ENSPANP00000029251 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Nuclear receptor coactivator. | 0.998 |
| ESR1 | NCOR1 | ENSPANP00000015224 | ENSPANP00000019731 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Nuclear receptor corepressor 1. | 0.996 |
| ESR1 | SP1 | ENSPANP00000015224 | ENSPANP00000009583 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Sp1 transcription factor. | 0.996 |
| ESR1 | SRC | ENSPANP00000015224 | ENSPANP00000029342 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Tyrosine-protein kinase. | 0.997 |
| ESR2 | AKT1 | ENSPANP00000017082 | ENSPANP00000013336 | Uncharacterized protein. | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | 0.968 |
| ESR2 | ESR1 | ENSPANP00000017082 | ENSPANP00000015224 | Uncharacterized protein. | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | 0.999 |
| ESR2 | FOS | ENSPANP00000017082 | ENSPANP00000015872 | Uncharacterized protein. | Fos proto-oncogene, AP-1 transcription factor subunit. | 0.978 |
| ESR2 | MED1 | ENSPANP00000017082 | ENSPANP00000020534 | Uncharacterized protein. | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | 0.993 |
| ESR2 | NCOA1 | ENSPANP00000017082 | ENSPANP00000043481 | Uncharacterized protein. | Nuclear receptor coactivator. | 0.994 |
| ESR2 | NCOA2 | ENSPANP00000017082 | ENSPANP00000006814 | Uncharacterized protein. | Nuclear receptor coactivator. | 0.985 |
