STK4 protein (Papio anubis) - STRING interaction network

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STK4

Serine/threonine-protein kinase 4 18kDa subunit; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regul [...] (487 aa)

Predicted Functional Partners:

RASSF1

0.988

STK3

0.977

SAV1

0.969

MOB1A

0.941

ENSPANP00000030561

0.941

RASSF5

0.916

FOXO3

0.914

FOXO1

0.914

RASSF2

0.914

FOXO4

0.911

Your Current Organism:

Papio anubis

NCBI taxonomy Id: 9555
Other names: Anubis baboon, Doguera baboon, Kenya baboon, P. anubis, Papio cynocephalus anubis, Papio doguera, Papio hamadryas anubis, Papio hamadryas doguera, baboon, olive baboon

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPANP00000030561	SAV1	ENSPANP00000030561	ENSPANP00000016850	Uncharacterized protein.	Salvador family WW domain containing protein 1.	0.746
ENSPANP00000030561	STK3	ENSPANP00000030561	ENSPANP00000043121	Uncharacterized protein.	Serine/threonine kinase 3.	0.936
ENSPANP00000030561	STK4	ENSPANP00000030561	ENSPANP00000017674	Uncharacterized protein.	Serine/threonine-protein kinase 4 18kDa subunit; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regul [...]	0.941
FOXO1	FOXO3	ENSPANP00000008419	ENSPANP00000004459	Forkhead box O1.	Forkhead box O3.	0.914
FOXO1	FOXO4	ENSPANP00000008419	ENSPANP00000044448	Forkhead box O1.	Forkhead box O4.	0.890
FOXO1	STK3	ENSPANP00000008419	ENSPANP00000043121	Forkhead box O1.	Serine/threonine kinase 3.	0.505
FOXO1	STK4	ENSPANP00000008419	ENSPANP00000017674	Forkhead box O1.	Serine/threonine-protein kinase 4 18kDa subunit; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regul [...]	0.914
FOXO3	FOXO1	ENSPANP00000004459	ENSPANP00000008419	Forkhead box O3.	Forkhead box O1.	0.914
FOXO3	FOXO4	ENSPANP00000004459	ENSPANP00000044448	Forkhead box O3.	Forkhead box O4.	0.888
FOXO3	STK3	ENSPANP00000004459	ENSPANP00000043121	Forkhead box O3.	Serine/threonine kinase 3.	0.505
FOXO3	STK4	ENSPANP00000004459	ENSPANP00000017674	Forkhead box O3.	Serine/threonine-protein kinase 4 18kDa subunit; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regul [...]	0.914
FOXO4	FOXO1	ENSPANP00000044448	ENSPANP00000008419	Forkhead box O4.	Forkhead box O1.	0.890
FOXO4	FOXO3	ENSPANP00000044448	ENSPANP00000004459	Forkhead box O4.	Forkhead box O3.	0.888
FOXO4	STK3	ENSPANP00000044448	ENSPANP00000043121	Forkhead box O4.	Serine/threonine kinase 3.	0.625
FOXO4	STK4	ENSPANP00000044448	ENSPANP00000017674	Forkhead box O4.	Serine/threonine-protein kinase 4 18kDa subunit; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regul [...]	0.911
MOB1A	SAV1	ENSPANP00000023156	ENSPANP00000016850	Uncharacterized protein.	Salvador family WW domain containing protein 1.	0.746
MOB1A	STK3	ENSPANP00000023156	ENSPANP00000043121	Uncharacterized protein.	Serine/threonine kinase 3.	0.984
MOB1A	STK4	ENSPANP00000023156	ENSPANP00000017674	Uncharacterized protein.	Serine/threonine-protein kinase 4 18kDa subunit; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regul [...]	0.941
RASSF1	RASSF5	ENSPANP00000005719	ENSPANP00000004950	Ras association domain family member 1.	Ras association domain family member 5.	0.939
RASSF1	SAV1	ENSPANP00000005719	ENSPANP00000016850	Ras association domain family member 1.	Salvador family WW domain containing protein 1.	0.778

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