| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AKT1 | AKT2 | ENSPANP00000013336 | ENSPANP00000046066 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | 0.999 |
| AKT1 | AKT3 | ENSPANP00000013336 | ENSPANP00000002368 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | 0.995 |
| AKT1 | ATM | ENSPANP00000013336 | ENSPANP00000010521 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | 0.524 |
| AKT1 | CDKN2B | ENSPANP00000013336 | ENSPANP00000022281 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Uncharacterized protein. | 0.437 |
| AKT1 | DLG4 | ENSPANP00000013336 | ENSPANP00000019603 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family. | 0.402 |
| AKT1 | IRF1 | ENSPANP00000013336 | ENSPANP00000003146 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Interferon regulatory factor. | 0.428 |
| AKT1 | MDM2 | ENSPANP00000013336 | ENSPANP00000018248 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. | 0.989 |
| AKT1 | MDM4 | ENSPANP00000013336 | ENSPANP00000004949 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. | 0.627 |
| AKT1 | TP53 | ENSPANP00000013336 | ENSPANP00000033477 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.975 |
| AKT2 | AKT1 | ENSPANP00000046066 | ENSPANP00000013336 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | 0.999 |
| AKT2 | AKT3 | ENSPANP00000046066 | ENSPANP00000002368 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | 0.991 |
| AKT2 | ATM | ENSPANP00000046066 | ENSPANP00000010521 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | 0.407 |
| AKT2 | MDM2 | ENSPANP00000046066 | ENSPANP00000018248 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. | 0.984 |
| AKT2 | MDM4 | ENSPANP00000046066 | ENSPANP00000004949 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. | 0.586 |
| AKT2 | TP53 | ENSPANP00000046066 | ENSPANP00000033477 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.944 |
| AKT3 | AKT1 | ENSPANP00000002368 | ENSPANP00000013336 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | 0.995 |
| AKT3 | AKT2 | ENSPANP00000002368 | ENSPANP00000046066 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | 0.991 |
| AKT3 | ATM | ENSPANP00000002368 | ENSPANP00000010521 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | 0.407 |
| AKT3 | MDM2 | ENSPANP00000002368 | ENSPANP00000018248 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. | 0.984 |
| AKT3 | MDM4 | ENSPANP00000002368 | ENSPANP00000004949 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. | 0.587 |
