node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATM | BCL2 | ENSPANP00000010521 | ENSPANP00000001764 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | BCL2 apoptosis regulator. | 0.401 |
ATM | EP300 | ENSPANP00000010521 | ENSPANP00000013403 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | E1A binding protein p300. | 0.489 |
ATM | MDM2 | ENSPANP00000010521 | ENSPANP00000018248 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. | 0.950 |
ATM | MDM4 | ENSPANP00000010521 | ENSPANP00000004949 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. | 0.841 |
ATM | TP53 | ENSPANP00000010521 | ENSPANP00000033477 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.996 |
BAK1 | BAX | ENSPANP00000039349 | ENSPANP00000036654 | BCL2 antagonist/killer 1. | BCL2 associated X, apoptosis regulator. | 0.994 |
BAK1 | BCL2 | ENSPANP00000039349 | ENSPANP00000001764 | BCL2 antagonist/killer 1. | BCL2 apoptosis regulator. | 0.999 |
BAK1 | TP53 | ENSPANP00000039349 | ENSPANP00000033477 | BCL2 antagonist/killer 1. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.999 |
BAX | BAK1 | ENSPANP00000036654 | ENSPANP00000039349 | BCL2 associated X, apoptosis regulator. | BCL2 antagonist/killer 1. | 0.994 |
BAX | BCL2 | ENSPANP00000036654 | ENSPANP00000001764 | BCL2 associated X, apoptosis regulator. | BCL2 apoptosis regulator. | 0.998 |
BAX | TP53 | ENSPANP00000036654 | ENSPANP00000033477 | BCL2 associated X, apoptosis regulator. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.995 |
BCL2 | ATM | ENSPANP00000001764 | ENSPANP00000010521 | BCL2 apoptosis regulator. | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | 0.401 |
BCL2 | BAK1 | ENSPANP00000001764 | ENSPANP00000039349 | BCL2 apoptosis regulator. | BCL2 antagonist/killer 1. | 0.999 |
BCL2 | BAX | ENSPANP00000001764 | ENSPANP00000036654 | BCL2 apoptosis regulator. | BCL2 associated X, apoptosis regulator. | 0.998 |
BCL2 | EP300 | ENSPANP00000001764 | ENSPANP00000013403 | BCL2 apoptosis regulator. | E1A binding protein p300. | 0.422 |
BCL2 | MDM2 | ENSPANP00000001764 | ENSPANP00000018248 | BCL2 apoptosis regulator. | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. | 0.614 |
BCL2 | MDM4 | ENSPANP00000001764 | ENSPANP00000004949 | BCL2 apoptosis regulator. | Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. | 0.438 |
BCL2 | TP53 | ENSPANP00000001764 | ENSPANP00000033477 | BCL2 apoptosis regulator. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.995 |
CREBBP | EP300 | ENSPANP00000013793 | ENSPANP00000013403 | CREB binding protein. | E1A binding protein p300. | 0.997 |
CREBBP | MDM2 | ENSPANP00000013793 | ENSPANP00000018248 | CREB binding protein. | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. | 0.693 |