node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
NPC1 | TMEM97 | ENSPANP00000002787 | ENSPANP00000019807 | NPC intracellular cholesterol transporter 1. | Transmembrane protein 97; Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cells. Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation. May play a role as a regulator of cellular cholesterol homeostasis. May function as sterol isomerase. May alter the activity of some cytochrome P450 proteins. | 0.468 |
PDE10A | PDE4A | ENSPANP00000041497 | ENSPANP00000002853 | Phosphodiesterase. | Phosphodiesterase. | 0.578 |
PDE10A | TMEM97 | ENSPANP00000041497 | ENSPANP00000019807 | Phosphodiesterase. | Transmembrane protein 97; Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cells. Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation. May play a role as a regulator of cellular cholesterol homeostasis. May function as sterol isomerase. May alter the activity of some cytochrome P450 proteins. | 0.581 |
PDE4A | PDE10A | ENSPANP00000002853 | ENSPANP00000041497 | Phosphodiesterase. | Phosphodiesterase. | 0.578 |
PDE4A | TMEM97 | ENSPANP00000002853 | ENSPANP00000019807 | Phosphodiesterase. | Transmembrane protein 97; Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cells. Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation. May play a role as a regulator of cellular cholesterol homeostasis. May function as sterol isomerase. May alter the activity of some cytochrome P450 proteins. | 0.574 |
PGRMC1 | TMEM97 | ENSPANP00000007267 | ENSPANP00000019807 | Progesterone receptor membrane component 1; Belongs to the cytochrome b5 family. | Transmembrane protein 97; Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cells. Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation. May play a role as a regulator of cellular cholesterol homeostasis. May function as sterol isomerase. May alter the activity of some cytochrome P450 proteins. | 0.574 |
SAMD13 | TMEM97 | ENSPANP00000037680 | ENSPANP00000019807 | Sterile alpha motif domain containing 13. | Transmembrane protein 97; Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cells. Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation. May play a role as a regulator of cellular cholesterol homeostasis. May function as sterol isomerase. May alter the activity of some cytochrome P450 proteins. | 0.577 |
SIGMAR1 | TMEM97 | ENSPANP00000019132 | ENSPANP00000019807 | Sigma non-opioid intracellular receptor 1. | Transmembrane protein 97; Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cells. Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation. May play a role as a regulator of cellular cholesterol homeostasis. May function as sterol isomerase. May alter the activity of some cytochrome P450 proteins. | 0.427 |
TAAR1 | TMEM97 | ENSPANP00000004682 | ENSPANP00000019807 | Trace amine associated receptor 1; Belongs to the G-protein coupled receptor 1 family. | Transmembrane protein 97; Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cells. Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation. May play a role as a regulator of cellular cholesterol homeostasis. May function as sterol isomerase. May alter the activity of some cytochrome P450 proteins. | 0.583 |
TMEM97 | NPC1 | ENSPANP00000019807 | ENSPANP00000002787 | Transmembrane protein 97; Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cells. Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation. May play a role as a regulator of cellular cholesterol homeostasis. May function as sterol isomerase. May alter the activity of some cytochrome P450 proteins. | NPC intracellular cholesterol transporter 1. | 0.468 |
TMEM97 | PDE10A | ENSPANP00000019807 | ENSPANP00000041497 | Transmembrane protein 97; Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cells. Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation. May play a role as a regulator of cellular cholesterol homeostasis. May function as sterol isomerase. May alter the activity of some cytochrome P450 proteins. | Phosphodiesterase. | 0.581 |
TMEM97 | PDE4A | ENSPANP00000019807 | ENSPANP00000002853 | Transmembrane protein 97; Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cells. Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation. May play a role as a regulator of cellular cholesterol homeostasis. May function as sterol isomerase. May alter the activity of some cytochrome P450 proteins. | Phosphodiesterase. | 0.574 |
TMEM97 | PGRMC1 | ENSPANP00000019807 | ENSPANP00000007267 | Transmembrane protein 97; Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cells. Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation. May play a role as a regulator of cellular cholesterol homeostasis. May function as sterol isomerase. May alter the activity of some cytochrome P450 proteins. | Progesterone receptor membrane component 1; Belongs to the cytochrome b5 family. | 0.574 |
TMEM97 | SAMD13 | ENSPANP00000019807 | ENSPANP00000037680 | Transmembrane protein 97; Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cells. Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation. May play a role as a regulator of cellular cholesterol homeostasis. May function as sterol isomerase. May alter the activity of some cytochrome P450 proteins. | Sterile alpha motif domain containing 13. | 0.577 |
TMEM97 | SIGMAR1 | ENSPANP00000019807 | ENSPANP00000019132 | Transmembrane protein 97; Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cells. Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation. May play a role as a regulator of cellular cholesterol homeostasis. May function as sterol isomerase. May alter the activity of some cytochrome P450 proteins. | Sigma non-opioid intracellular receptor 1. | 0.427 |
TMEM97 | TAAR1 | ENSPANP00000019807 | ENSPANP00000004682 | Transmembrane protein 97; Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cells. Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation. May play a role as a regulator of cellular cholesterol homeostasis. May function as sterol isomerase. May alter the activity of some cytochrome P450 proteins. | Trace amine associated receptor 1; Belongs to the G-protein coupled receptor 1 family. | 0.583 |