| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| APPBP2 | NME8 | ENSPANP00000020421 | ENSPANP00000003349 | Amyloid beta precursor protein binding protein 2. | NME/NM23 family member 8. | 0.466 |
| APPBP2 | PPM1D | ENSPANP00000020421 | ENSPANP00000020417 | Amyloid beta precursor protein binding protein 2. | Protein phosphatase, Mg2+/Mn2+ dependent 1D. | 0.598 |
| CBFB | PPM1D | ENSPANP00000013055 | ENSPANP00000020417 | Core-binding factor subunit beta. | Protein phosphatase, Mg2+/Mn2+ dependent 1D. | 0.823 |
| CBFB | RUNX1 | ENSPANP00000013055 | ENSPANP00000025646 | Core-binding factor subunit beta. | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. | 0.992 |
| CBFB | RUNX2 | ENSPANP00000013055 | ENSPANP00000022080 | Core-binding factor subunit beta. | RUNX family transcription factor 2. | 0.985 |
| CHEK2 | H2AX | ENSPANP00000015649 | ENSPANP00000008616 | Checkpoint kinase 2. | Histone H2A; Belongs to the histone H2A family. | 0.560 |
| CHEK2 | MDM2 | ENSPANP00000015649 | ENSPANP00000018248 | Checkpoint kinase 2. | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. | 0.969 |
| CHEK2 | PPM1D | ENSPANP00000015649 | ENSPANP00000020417 | Checkpoint kinase 2. | Protein phosphatase, Mg2+/Mn2+ dependent 1D. | 0.782 |
| CHEK2 | TP53 | ENSPANP00000015649 | ENSPANP00000033477 | Checkpoint kinase 2. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.999 |
| H2AX | CHEK2 | ENSPANP00000008616 | ENSPANP00000015649 | Histone H2A; Belongs to the histone H2A family. | Checkpoint kinase 2. | 0.560 |
| H2AX | PPM1D | ENSPANP00000008616 | ENSPANP00000020417 | Histone H2A; Belongs to the histone H2A family. | Protein phosphatase, Mg2+/Mn2+ dependent 1D. | 0.678 |
| H2AX | TP53 | ENSPANP00000008616 | ENSPANP00000033477 | Histone H2A; Belongs to the histone H2A family. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.622 |
| MDM2 | CHEK2 | ENSPANP00000018248 | ENSPANP00000015649 | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. | Checkpoint kinase 2. | 0.969 |
| MDM2 | PPM1D | ENSPANP00000018248 | ENSPANP00000020417 | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. | Protein phosphatase, Mg2+/Mn2+ dependent 1D. | 0.666 |
| MDM2 | RUNX1 | ENSPANP00000018248 | ENSPANP00000025646 | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. | 0.712 |
| MDM2 | RUNX2 | ENSPANP00000018248 | ENSPANP00000022080 | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. | RUNX family transcription factor 2. | 0.712 |
| MDM2 | TP53 | ENSPANP00000018248 | ENSPANP00000033477 | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.999 |
| NME8 | APPBP2 | ENSPANP00000003349 | ENSPANP00000020421 | NME/NM23 family member 8. | Amyloid beta precursor protein binding protein 2. | 0.466 |
| NME8 | PPM1D | ENSPANP00000003349 | ENSPANP00000020417 | NME/NM23 family member 8. | Protein phosphatase, Mg2+/Mn2+ dependent 1D. | 0.622 |
| NME8 | WDR90 | ENSPANP00000003349 | ENSPANP00000013480 | NME/NM23 family member 8. | WD repeat domain 90. | 0.839 |
