| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CSNK2A1 | CSNK2A2 | ENSPANP00000016911 | ENSPANP00000012952 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | Casein kinase 2 alpha 2; Belongs to the protein kinase superfamily. | 0.998 |
| CSNK2A1 | PTEN | ENSPANP00000016911 | ENSPANP00000020539 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. | 0.981 |
| CSNK2A1 | TP53 | ENSPANP00000016911 | ENSPANP00000033477 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.924 |
| CSNK2A2 | CSNK2A1 | ENSPANP00000012952 | ENSPANP00000016911 | Casein kinase 2 alpha 2; Belongs to the protein kinase superfamily. | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | 0.998 |
| CSNK2A2 | PTEN | ENSPANP00000012952 | ENSPANP00000020539 | Casein kinase 2 alpha 2; Belongs to the protein kinase superfamily. | Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. | 0.978 |
| CSNK2A2 | TP53 | ENSPANP00000012952 | ENSPANP00000033477 | Casein kinase 2 alpha 2; Belongs to the protein kinase superfamily. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.929 |
| MAGI2 | PTEN | ENSPANP00000039962 | ENSPANP00000020539 | Membrane associated guanylate kinase, WW and PDZ domain containing 2. | Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. | 0.987 |
| PIK3C3 | PIK3CA | ENSPANP00000040694 | ENSPANP00000004862 | Phosphatidylinositol 3-kinase catalytic subunit type 3. | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. | 0.889 |
| PIK3C3 | PIK3CB | ENSPANP00000040694 | ENSPANP00000033644 | Phosphatidylinositol 3-kinase catalytic subunit type 3. | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. | 0.886 |
| PIK3C3 | PIK3CD | ENSPANP00000040694 | ENSPANP00000014975 | Phosphatidylinositol 3-kinase catalytic subunit type 3. | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. | 0.843 |
| PIK3C3 | PIK3R1 | ENSPANP00000040694 | ENSPANP00000001366 | Phosphatidylinositol 3-kinase catalytic subunit type 3. | Phosphoinositide-3-kinase regulatory subunit 1. | 0.978 |
| PIK3C3 | PTEN | ENSPANP00000040694 | ENSPANP00000020539 | Phosphatidylinositol 3-kinase catalytic subunit type 3. | Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. | 0.983 |
| PIK3C3 | TP53 | ENSPANP00000040694 | ENSPANP00000033477 | Phosphatidylinositol 3-kinase catalytic subunit type 3. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.434 |
| PIK3CA | PIK3C3 | ENSPANP00000004862 | ENSPANP00000040694 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. | Phosphatidylinositol 3-kinase catalytic subunit type 3. | 0.889 |
| PIK3CA | PIK3CB | ENSPANP00000004862 | ENSPANP00000033644 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. | 0.990 |
| PIK3CA | PIK3CD | ENSPANP00000004862 | ENSPANP00000014975 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. | 0.988 |
| PIK3CA | PIK3R1 | ENSPANP00000004862 | ENSPANP00000001366 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. | Phosphoinositide-3-kinase regulatory subunit 1. | 0.999 |
| PIK3CA | PTEN | ENSPANP00000004862 | ENSPANP00000020539 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. | Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. | 0.990 |
| PIK3CA | PTK2 | ENSPANP00000004862 | ENSPANP00000043126 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. | Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. | 0.989 |
| PIK3CA | TP53 | ENSPANP00000004862 | ENSPANP00000033477 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.869 |
