| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ENSPANP00000046574 | GSE1 | ENSPANP00000046574 | ENSPANP00000031689 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. | Gse1 coiled-coil protein. | 0.778 |
| ENSPANP00000046574 | HDAC2 | ENSPANP00000046574 | ENSPANP00000015145 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. | Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. | 0.997 |
| ENSPANP00000046574 | HMG20A | ENSPANP00000046574 | ENSPANP00000014308 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. | High mobility group 20A. | 0.836 |
| ENSPANP00000046574 | HMG20B | ENSPANP00000046574 | ENSPANP00000000973 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. | High mobility group 20B. | 0.897 |
| ENSPANP00000046574 | KDM1A | ENSPANP00000046574 | ENSPANP00000031447 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. | 0.947 |
| ENSPANP00000046574 | RCOR1 | ENSPANP00000046574 | ENSPANP00000013256 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. | REST corepressor 1. | 0.940 |
| ENSPANP00000046574 | RCOR3 | ENSPANP00000046574 | ENSPANP00000002512 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. | REST corepressor 3. | 0.867 |
| ENSPANP00000046574 | SNAI1 | ENSPANP00000046574 | ENSPANP00000014614 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. | Snail family transcriptional repressor 1. | 0.881 |
| FGF1 | GSE1 | ENSPANP00000008321 | ENSPANP00000031689 | Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] | Gse1 coiled-coil protein. | 0.815 |
| FGF1 | HMG20A | ENSPANP00000008321 | ENSPANP00000014308 | Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] | High mobility group 20A. | 0.684 |
| GSE1 | ENSPANP00000046574 | ENSPANP00000031689 | ENSPANP00000046574 | Gse1 coiled-coil protein. | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. | 0.778 |
| GSE1 | FGF1 | ENSPANP00000031689 | ENSPANP00000008321 | Gse1 coiled-coil protein. | Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] | 0.815 |
| GSE1 | HDAC1 | ENSPANP00000031689 | ENSPANP00000004176 | Gse1 coiled-coil protein. | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. | 0.778 |
| GSE1 | HDAC2 | ENSPANP00000031689 | ENSPANP00000015145 | Gse1 coiled-coil protein. | Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. | 0.832 |
| GSE1 | HMG20A | ENSPANP00000031689 | ENSPANP00000014308 | Gse1 coiled-coil protein. | High mobility group 20A. | 0.936 |
| GSE1 | HMG20B | ENSPANP00000031689 | ENSPANP00000000973 | Gse1 coiled-coil protein. | High mobility group 20B. | 0.940 |
| GSE1 | KDM1A | ENSPANP00000031689 | ENSPANP00000031447 | Gse1 coiled-coil protein. | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. | 0.852 |
| GSE1 | RCOR1 | ENSPANP00000031689 | ENSPANP00000013256 | Gse1 coiled-coil protein. | REST corepressor 1. | 0.794 |
| GSE1 | RCOR3 | ENSPANP00000031689 | ENSPANP00000002512 | Gse1 coiled-coil protein. | REST corepressor 3. | 0.848 |
| GSE1 | SNAI1 | ENSPANP00000031689 | ENSPANP00000014614 | Gse1 coiled-coil protein. | Snail family transcriptional repressor 1. | 0.903 |
