node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AMD1 | DNMT1 | ENSPANP00000011517 | ENSPANP00000000133 | S-adenosylmethionine decarboxylase proenzyme. | DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | 0.896 |
AMD1 | ENSPANP00000022020 | ENSPANP00000011517 | ENSPANP00000022020 | S-adenosylmethionine decarboxylase proenzyme. | Methionine adenosyltransferase 2 subunit beta; Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. | 0.426 |
AMD1 | ENSPANP00000033977 | ENSPANP00000011517 | ENSPANP00000033977 | S-adenosylmethionine decarboxylase proenzyme. | Uncharacterized protein. | 0.896 |
AMD1 | MAT1A | ENSPANP00000011517 | ENSPANP00000020235 | S-adenosylmethionine decarboxylase proenzyme. | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. | 0.919 |
AMD1 | MAT2B | ENSPANP00000011517 | ENSPANP00000009470 | S-adenosylmethionine decarboxylase proenzyme. | Methionine adenosyltransferase 2 subunit beta; Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. | 0.898 |
AMD1 | MTR | ENSPANP00000011517 | ENSPANP00000017831 | S-adenosylmethionine decarboxylase proenzyme. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.426 |
AMD1 | TAT | ENSPANP00000011517 | ENSPANP00000015998 | S-adenosylmethionine decarboxylase proenzyme. | Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. | 0.466 |
BHMT | ENSPANP00000022020 | ENSPANP00000000909 | ENSPANP00000022020 | Betaine--homocysteine S-methyltransferase. | Methionine adenosyltransferase 2 subunit beta; Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. | 0.675 |
BHMT | ENSPANP00000033977 | ENSPANP00000000909 | ENSPANP00000033977 | Betaine--homocysteine S-methyltransferase. | Uncharacterized protein. | 0.909 |
BHMT | MAT1A | ENSPANP00000000909 | ENSPANP00000020235 | Betaine--homocysteine S-methyltransferase. | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. | 0.934 |
BHMT | MAT2B | ENSPANP00000000909 | ENSPANP00000009470 | Betaine--homocysteine S-methyltransferase. | Methionine adenosyltransferase 2 subunit beta; Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. | 0.922 |
BHMT | MTHFR | ENSPANP00000000909 | ENSPANP00000008861 | Betaine--homocysteine S-methyltransferase. | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.977 |
BHMT | MTR | ENSPANP00000000909 | ENSPANP00000017831 | Betaine--homocysteine S-methyltransferase. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.945 |
BHMT | TAT | ENSPANP00000000909 | ENSPANP00000015998 | Betaine--homocysteine S-methyltransferase. | Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. | 0.918 |
DNMT1 | AMD1 | ENSPANP00000000133 | ENSPANP00000011517 | DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | S-adenosylmethionine decarboxylase proenzyme. | 0.896 |
DNMT1 | DNMT3B | ENSPANP00000000133 | ENSPANP00000042114 | DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | DNA methyltransferase 3 beta; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | 0.999 |
DNMT1 | ENSPANP00000022020 | ENSPANP00000000133 | ENSPANP00000022020 | DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | Methionine adenosyltransferase 2 subunit beta; Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. | 0.620 |
DNMT1 | ENSPANP00000033977 | ENSPANP00000000133 | ENSPANP00000033977 | DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | Uncharacterized protein. | 0.871 |
DNMT1 | MAT1A | ENSPANP00000000133 | ENSPANP00000020235 | DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. | 0.899 |
DNMT1 | MAT2B | ENSPANP00000000133 | ENSPANP00000009470 | DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | Methionine adenosyltransferase 2 subunit beta; Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. | 0.910 |