node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
F2 | F2R | ENSPANP00000044950 | ENSPANP00000003938 | Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. | Coagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. | 0.992 |
F2 | F8 | ENSPANP00000044950 | ENSPANP00000018099 | Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. | Coagulation factor VIII; Belongs to the multicopper oxidase family. | 0.977 |
F2 | PROC | ENSPANP00000044950 | ENSPANP00000043025 | Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. | Protein C, inactivator of coagulation factors Va and VIIIa. | 0.986 |
F2 | PROCR | ENSPANP00000044950 | ENSPANP00000016776 | Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. | Protein C receptor. | 0.778 |
F2 | SERPINA1 | ENSPANP00000044950 | ENSPANP00000013142 | Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. | Alpha-1-antitrypsin; Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Inhibits trypsin, chymotrypsin and plasminogen activator (By similarity); Belongs to the serpin family. | 0.648 |
F2 | SERPINA5 | ENSPANP00000044950 | ENSPANP00000013153 | Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. | Serpin family A member 5; Belongs to the serpin family. | 0.985 |
F2 | SERPINB2 | ENSPANP00000044950 | ENSPANP00000004441 | Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. | Serpin peptidase inhibitor, clade B, member 2 (Predicted); Belongs to the serpin family. | 0.677 |
F2 | SERPINC1 | ENSPANP00000044950 | ENSPANP00000005858 | Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. | Serpin family C member 1; Belongs to the serpin family. | 0.998 |
F2 | SERPINE1 | ENSPANP00000044950 | ENSPANP00000021937 | Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. | Serpin family E member 1; Belongs to the serpin family. | 0.438 |
F2 | SERPINF2 | ENSPANP00000044950 | ENSPANP00000019482 | Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. | Serpin family F member 2; Belongs to the serpin family. | 0.874 |
F2R | F2 | ENSPANP00000003938 | ENSPANP00000044950 | Coagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. | Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. | 0.992 |
F2R | PROC | ENSPANP00000003938 | ENSPANP00000043025 | Coagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. | Protein C, inactivator of coagulation factors Va and VIIIa. | 0.913 |
F2R | PROCR | ENSPANP00000003938 | ENSPANP00000016776 | Coagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. | Protein C receptor. | 0.792 |
F8 | F2 | ENSPANP00000018099 | ENSPANP00000044950 | Coagulation factor VIII; Belongs to the multicopper oxidase family. | Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. | 0.977 |
F8 | PROC | ENSPANP00000018099 | ENSPANP00000043025 | Coagulation factor VIII; Belongs to the multicopper oxidase family. | Protein C, inactivator of coagulation factors Va and VIIIa. | 0.931 |
F8 | SERPINC1 | ENSPANP00000018099 | ENSPANP00000005858 | Coagulation factor VIII; Belongs to the multicopper oxidase family. | Serpin family C member 1; Belongs to the serpin family. | 0.747 |
PROC | F2 | ENSPANP00000043025 | ENSPANP00000044950 | Protein C, inactivator of coagulation factors Va and VIIIa. | Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. | 0.986 |
PROC | F2R | ENSPANP00000043025 | ENSPANP00000003938 | Protein C, inactivator of coagulation factors Va and VIIIa. | Coagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. | 0.913 |
PROC | F8 | ENSPANP00000043025 | ENSPANP00000018099 | Protein C, inactivator of coagulation factors Va and VIIIa. | Coagulation factor VIII; Belongs to the multicopper oxidase family. | 0.931 |
PROC | PROCR | ENSPANP00000043025 | ENSPANP00000016776 | Protein C, inactivator of coagulation factors Va and VIIIa. | Protein C receptor. | 0.974 |