node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CACNA1A | CDKL5 | ENSPANP00000008529 | ENSPANP00000043055 | Voltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. | Cyclin dependent kinase like 5. | 0.525 |
CACNA1A | FOXG1 | ENSPANP00000008529 | ENSPANP00000017735 | Voltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. | Forkhead box G1. | 0.477 |
CACNA1A | PRAF2 | ENSPANP00000008529 | ENSPANP00000002251 | Voltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. | Uncharacterized protein. | 0.666 |
CACNA1A | STXBP1 | ENSPANP00000008529 | ENSPANP00000019378 | Voltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. | Syntaxin binding protein 1; Belongs to the STXBP/unc-18/SEC1 family. | 0.493 |
CDKL5 | CACNA1A | ENSPANP00000043055 | ENSPANP00000008529 | Cyclin dependent kinase like 5. | Voltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. | 0.525 |
CDKL5 | FOXG1 | ENSPANP00000043055 | ENSPANP00000017735 | Cyclin dependent kinase like 5. | Forkhead box G1. | 0.563 |
CDKL5 | HPS6 | ENSPANP00000043055 | ENSPANP00000004764 | Cyclin dependent kinase like 5. | Hermansky-Pudlak syndrome 6 protein homolog; May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. | 0.573 |
CDKL5 | MECP2 | ENSPANP00000043055 | ENSPANP00000040329 | Cyclin dependent kinase like 5. | Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). | 0.622 |
CDKL5 | PCDH19 | ENSPANP00000043055 | ENSPANP00000003582 | Cyclin dependent kinase like 5. | Protocadherin 19. | 0.602 |
CDKL5 | PRAF2 | ENSPANP00000043055 | ENSPANP00000002251 | Cyclin dependent kinase like 5. | Uncharacterized protein. | 0.515 |
CDKL5 | SCN1A | ENSPANP00000043055 | ENSPANP00000018412 | Cyclin dependent kinase like 5. | Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. | 0.595 |
CDKL5 | SCN2A | ENSPANP00000043055 | ENSPANP00000003752 | Cyclin dependent kinase like 5. | Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. | 0.525 |
CDKL5 | STXBP1 | ENSPANP00000043055 | ENSPANP00000019378 | Cyclin dependent kinase like 5. | Syntaxin binding protein 1; Belongs to the STXBP/unc-18/SEC1 family. | 0.579 |
CDKL5 | STXBP5 | ENSPANP00000043055 | ENSPANP00000007625 | Cyclin dependent kinase like 5. | Syntaxin binding protein 5. | 0.564 |
FOXG1 | CACNA1A | ENSPANP00000017735 | ENSPANP00000008529 | Forkhead box G1. | Voltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. | 0.477 |
FOXG1 | CDKL5 | ENSPANP00000017735 | ENSPANP00000043055 | Forkhead box G1. | Cyclin dependent kinase like 5. | 0.563 |
FOXG1 | MECP2 | ENSPANP00000017735 | ENSPANP00000040329 | Forkhead box G1. | Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). | 0.690 |
FOXG1 | PRAF2 | ENSPANP00000017735 | ENSPANP00000002251 | Forkhead box G1. | Uncharacterized protein. | 0.477 |
HPS6 | CDKL5 | ENSPANP00000004764 | ENSPANP00000043055 | Hermansky-Pudlak syndrome 6 protein homolog; May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. | Cyclin dependent kinase like 5. | 0.573 |
MECP2 | CDKL5 | ENSPANP00000040329 | ENSPANP00000043055 | Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). | Cyclin dependent kinase like 5. | 0.622 |