| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BARD1 | BLM | ENSPANP00000005319 | ENSPANP00000014473 | BRCA1 associated RING domain 1. | BLM RecQ like helicase. | 0.766 |
| BARD1 | BRCA1 | ENSPANP00000005319 | ENSPANP00000027226 | BRCA1 associated RING domain 1. | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | 0.999 |
| BARD1 | MRE11 | ENSPANP00000005319 | ENSPANP00000009957 | BRCA1 associated RING domain 1. | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. | 0.975 |
| BARD1 | NBN | ENSPANP00000005319 | ENSPANP00000015046 | BRCA1 associated RING domain 1. | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. | 0.979 |
| BARD1 | RTEL1 | ENSPANP00000005319 | ENSPANP00000047749 | BRCA1 associated RING domain 1. | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] | 0.914 |
| BARD1 | SLF1 | ENSPANP00000005319 | ENSPANP00000003676 | BRCA1 associated RING domain 1. | SMC5-SMC6 complex localization factor 1. | 0.915 |
| BARD1 | SLX4 | ENSPANP00000005319 | ENSPANP00000013784 | BRCA1 associated RING domain 1. | SLX4 structure-specific endonuclease subunit. | 0.706 |
| BARD1 | TOPBP1 | ENSPANP00000005319 | ENSPANP00000006180 | BRCA1 associated RING domain 1. | DNA topoisomerase II binding protein 1. | 0.978 |
| BARD1 | WRN | ENSPANP00000005319 | ENSPANP00000018132 | BRCA1 associated RING domain 1. | WRN RecQ like helicase. | 0.961 |
| BLM | BARD1 | ENSPANP00000014473 | ENSPANP00000005319 | BLM RecQ like helicase. | BRCA1 associated RING domain 1. | 0.766 |
| BLM | BRCA1 | ENSPANP00000014473 | ENSPANP00000027226 | BLM RecQ like helicase. | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | 0.951 |
| BLM | MRE11 | ENSPANP00000014473 | ENSPANP00000009957 | BLM RecQ like helicase. | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. | 0.949 |
| BLM | NBN | ENSPANP00000014473 | ENSPANP00000015046 | BLM RecQ like helicase. | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. | 0.945 |
| BLM | RTEL1 | ENSPANP00000014473 | ENSPANP00000047749 | BLM RecQ like helicase. | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] | 0.849 |
| BLM | SLF1 | ENSPANP00000014473 | ENSPANP00000003676 | BLM RecQ like helicase. | SMC5-SMC6 complex localization factor 1. | 0.834 |
| BLM | SLX4 | ENSPANP00000014473 | ENSPANP00000013784 | BLM RecQ like helicase. | SLX4 structure-specific endonuclease subunit. | 0.680 |
| BLM | TOPBP1 | ENSPANP00000014473 | ENSPANP00000006180 | BLM RecQ like helicase. | DNA topoisomerase II binding protein 1. | 0.904 |
| BLM | WRN | ENSPANP00000014473 | ENSPANP00000018132 | BLM RecQ like helicase. | WRN RecQ like helicase. | 0.607 |
| BRCA1 | BARD1 | ENSPANP00000027226 | ENSPANP00000005319 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | BRCA1 associated RING domain 1. | 0.999 |
| BRCA1 | BLM | ENSPANP00000027226 | ENSPANP00000014473 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | BLM RecQ like helicase. | 0.951 |
