Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
SHC3SHC adaptor protein 3. (594 aa)    
Predicted Functional Partners:
GRB2
Growth factor receptor bound protein 2.
    
 0.995
EGFR
Epidermal growth factor receptor.
    
 0.994
SOS1
SOS Ras/Rac guanine nucleotide exchange factor 1.
    
 0.990
ERBB2
Erb-b2 receptor tyrosine kinase 2.
    
 0.989
GAB1
GRB2 associated binding protein 1.
    
 0.988
INSR
Insulin receptor.
    
 0.987
NTRK2
Neurotrophic receptor tyrosine kinase 2.
    
 0.987
NTRK1
Neurotrophic receptor tyrosine kinase 1.
    
 0.986
SOS2
SOS Ras/Rho guanine nucleotide exchange factor 2.
    
 0.986
IGF1R
Insulin like growth factor 1 receptor.
    
 0.986
Your Current Organism:
Theropithecus gelada
NCBI taxonomy Id: 9565
Other names: T. gelada, bleeding heart baboon, gelada, gelada baboon
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