DRAXIN protein (Mandrillus leucophaeus) - STRING interaction network

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DRAXIN

Draxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. (349 aa)

Predicted Functional Partners:

NTN1

0.916

DCC

0.883

NTN3

0.754

ENSMLEP00000036061

0.751

ENSMLEP00000031147

0.744

SPICE1

0.742

NTN5

0.699

IGDCC4

0.682

IGDCC3

0.646

NTNG1

0.572

Your Current Organism:

Mandrillus leucophaeus

NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DCC	DRAXIN	ENSMLEP00000002524	ENSMLEP00000001082	DCC netrin 1 receptor.	Draxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway.	0.883
DCC	ENSMLEP00000036061	ENSMLEP00000002524	ENSMLEP00000036061	DCC netrin 1 receptor.	Uncharacterized protein.	0.899
DCC	NTN1	ENSMLEP00000002524	ENSMLEP00000031910	DCC netrin 1 receptor.	Netrin 1.	0.997
DCC	NTN3	ENSMLEP00000002524	ENSMLEP00000016612	DCC netrin 1 receptor.	Netrin 3.	0.929
DCC	NTN5	ENSMLEP00000002524	ENSMLEP00000026107	DCC netrin 1 receptor.	Netrin 5.	0.793
DCC	NTNG1	ENSMLEP00000002524	ENSMLEP00000022813	DCC netrin 1 receptor.	Netrin G1.	0.709
DRAXIN	DCC	ENSMLEP00000001082	ENSMLEP00000002524	Draxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway.	DCC netrin 1 receptor.	0.883
DRAXIN	ENSMLEP00000031147	ENSMLEP00000001082	ENSMLEP00000031147	Draxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway.	Neogenin_C domain-containing protein.	0.744
DRAXIN	ENSMLEP00000036061	ENSMLEP00000001082	ENSMLEP00000036061	Draxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway.	Uncharacterized protein.	0.751
DRAXIN	IGDCC3	ENSMLEP00000001082	ENSMLEP00000028313	Draxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway.	Immunoglobulin superfamily DCC subclass member 3.	0.646
DRAXIN	IGDCC4	ENSMLEP00000001082	ENSMLEP00000007996	Draxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway.	Immunoglobulin superfamily DCC subclass member 4.	0.682
DRAXIN	NTN1	ENSMLEP00000001082	ENSMLEP00000031910	Draxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway.	Netrin 1.	0.916
DRAXIN	NTN3	ENSMLEP00000001082	ENSMLEP00000016612	Draxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway.	Netrin 3.	0.754
DRAXIN	NTN5	ENSMLEP00000001082	ENSMLEP00000026107	Draxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway.	Netrin 5.	0.699
DRAXIN	NTNG1	ENSMLEP00000001082	ENSMLEP00000022813	Draxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway.	Netrin G1.	0.572
DRAXIN	SPICE1	ENSMLEP00000001082	ENSMLEP00000028147	Draxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway.	Uncharacterized protein.	0.742
ENSMLEP00000031147	DRAXIN	ENSMLEP00000031147	ENSMLEP00000001082	Neogenin_C domain-containing protein.	Draxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway.	0.744
ENSMLEP00000031147	ENSMLEP00000036061	ENSMLEP00000031147	ENSMLEP00000036061	Neogenin_C domain-containing protein.	Uncharacterized protein.	0.900
ENSMLEP00000031147	NTN1	ENSMLEP00000031147	ENSMLEP00000031910	Neogenin_C domain-containing protein.	Netrin 1.	0.943
ENSMLEP00000031147	NTN3	ENSMLEP00000031147	ENSMLEP00000016612	Neogenin_C domain-containing protein.	Netrin 3.	0.879

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