DRAXIN protein (Mandrillus leucophaeus) - STRING interaction network

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DRAXIN

Draxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. (349 aa)

Predicted Functional Partners:

NTN1

0.843

DCC

0.841

ENSMLEP00000031147

0.738

ENSMLEP00000036061

0.738

NTN3

0.731

NTN5

0.694

IGDCC4

0.638

COQ5

0.543

RNF10

0.504

MAD2L1BP

0.494

Your Current Organism:

Mandrillus leucophaeus

NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
COQ5	DRAXIN	ENSMLEP00000004689	ENSMLEP00000001082	2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; Methyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl- 6-methoxy-1,4-benzoquinol (DMQH2).	Draxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway.	0.543
COQ5	RNF10	ENSMLEP00000004689	ENSMLEP00000017349	2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; Methyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl- 6-methoxy-1,4-benzoquinol (DMQH2).	Ring finger protein 10.	0.585
DCC	DRAXIN	ENSMLEP00000002524	ENSMLEP00000001082	DCC netrin 1 receptor.	Draxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway.	0.841
DCC	ENSMLEP00000036061	ENSMLEP00000002524	ENSMLEP00000036061	DCC netrin 1 receptor.	Uncharacterized protein.	0.899
DCC	NTN1	ENSMLEP00000002524	ENSMLEP00000031910	DCC netrin 1 receptor.	Netrin 1.	0.999
DCC	NTN3	ENSMLEP00000002524	ENSMLEP00000016612	DCC netrin 1 receptor.	Netrin 3.	0.951
DCC	NTN5	ENSMLEP00000002524	ENSMLEP00000026107	DCC netrin 1 receptor.	Netrin 5.	0.805
DRAXIN	COQ5	ENSMLEP00000001082	ENSMLEP00000004689	Draxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway.	2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; Methyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl- 6-methoxy-1,4-benzoquinol (DMQH2).	0.543
DRAXIN	DCC	ENSMLEP00000001082	ENSMLEP00000002524	Draxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway.	DCC netrin 1 receptor.	0.841
DRAXIN	ENSMLEP00000031147	ENSMLEP00000001082	ENSMLEP00000031147	Draxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway.	Neogenin_C domain-containing protein.	0.738
DRAXIN	ENSMLEP00000036061	ENSMLEP00000001082	ENSMLEP00000036061	Draxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway.	Uncharacterized protein.	0.738
DRAXIN	IGDCC4	ENSMLEP00000001082	ENSMLEP00000007996	Draxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway.	Immunoglobulin superfamily DCC subclass member 4.	0.638
DRAXIN	MAD2L1BP	ENSMLEP00000001082	ENSMLEP00000008992	Draxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway.	MAD2L1 binding protein.	0.494
DRAXIN	NTN1	ENSMLEP00000001082	ENSMLEP00000031910	Draxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway.	Netrin 1.	0.843
DRAXIN	NTN3	ENSMLEP00000001082	ENSMLEP00000016612	Draxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway.	Netrin 3.	0.731
DRAXIN	NTN5	ENSMLEP00000001082	ENSMLEP00000026107	Draxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway.	Netrin 5.	0.694
DRAXIN	RNF10	ENSMLEP00000001082	ENSMLEP00000017349	Draxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway.	Ring finger protein 10.	0.504
ENSMLEP00000031147	DRAXIN	ENSMLEP00000031147	ENSMLEP00000001082	Neogenin_C domain-containing protein.	Draxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway.	0.738
ENSMLEP00000031147	ENSMLEP00000036061	ENSMLEP00000031147	ENSMLEP00000036061	Neogenin_C domain-containing protein.	Uncharacterized protein.	0.900
ENSMLEP00000031147	NTN1	ENSMLEP00000031147	ENSMLEP00000031910	Neogenin_C domain-containing protein.	Netrin 1.	0.945

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