Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
IRF4Interferon regulatory factor 4. (379 aa)    
Predicted Functional Partners:
BCL6
BCL6 transcription repressor.
    
 0.915
IL4
Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family.
   
 
 0.845
IL10
Interleukin 10.
    
 
 0.825
STAT6
Signal transducer and activator of transcription.
    
 0.819
SPI1
Spi-1 proto-oncogene.
   
 
 0.795
SPIB
ETS domain-containing protein.
   
 
 0.795
CD4
CD4 molecule.
   
 
 0.739
IRF1
Interferon regulatory factor.
   
 0.688
STAT3
Signal transducer and activator of transcription.
    
 0.686
BATF
Basic leucine zipper ATF-like transcription factor.
   
 
 0.672
Your Current Organism:
Mandrillus leucophaeus
NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill
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