STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PEA15Proliferation and apoptosis adaptor protein 15. (151 aa)    
Predicted Functional Partners:
MAPK1
Mitogen-activated protein kinase.
    
 0.965
MAPK3
Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.
    
 0.920
APAF1
Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.
    
 0.870
MAPK7
Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.
    
 0.850
APPL1
Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.
    
 0.799
APPL2
Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.
    
 0.799
MAPK11
Mitogen-activated protein kinase.
    
 0.633
MAPK12
Mitogen-activated protein kinase.
    
 0.633
MAPK13
Mitogen-activated protein kinase.
    
 0.633
MAPK14
Mitogen-activated protein kinase.
    
 0.633
Your Current Organism:
Mandrillus leucophaeus
NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill
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