Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
LOC105540552Iso_dh domain-containing protein. (288 aa)    
Predicted Functional Partners:
IDH3B
Isocitrate dehydrogenase [NAD] subunit, mitochondrial.
   
 0.991
IDH3G
Isocitrate dehydrogenase [NAD] subunit, mitochondrial.
   
 0.987
CS
Citrate synthase; Belongs to the citrate synthase family.
  
 0.938
ACO2
Aconitase 2.
  
 0.930
ENSMLEP00000036394
Uncharacterized protein.
  
 0.930
PDHB
Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.
   
 0.888
MDH2
Malate dehydrogenase.
  
 0.878
OGDHL
Oxoglutarate dehydrogenase like.
   
 0.846
OGDH
Oxoglutarate dehydrogenase.
   
 0.846
SUCLG1
Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.
  
 
 0.838
Your Current Organism:
Mandrillus leucophaeus
NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill
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