Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PTCH2Patched 2. (1203 aa)    
Predicted Functional Partners:
SMO
Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.
    
 0.995
IHH
Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.
   
 0.993
ENSMLEP00000037023
HH_signal domain-containing protein.
   
 0.993
DHH
Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.
   
 0.985
BOC
BOC cell adhesion associated, oncogene regulated.
    
 0.980
CDON
Cell adhesion associated, oncogene regulated.
    
 0.980
SMURF2
SMAD specific E3 ubiquitin protein ligase 2.
    
 0.972
SMURF1
E3 ubiquitin-protein ligase.
    
 0.972
LRP2
LDL receptor related protein 2.
    
 0.912
PTCH1
Patched 1.
  
  
 
0.909
Your Current Organism:
Mandrillus leucophaeus
NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill
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