Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
ARHGEF3Rho guanine nucleotide exchange factor 3. (558 aa)    
Predicted Functional Partners:
RHOA
Ras homolog family member A.
    
 0.823
MAGI1
Membrane associated guanylate kinase, WW and PDZ domain containing 1.
    
   0.746
RHOB
Ras homolog family member B.
    
 0.738
RHOC
Ras homolog family member C.
    
 0.661
GNA13
G protein subunit alpha 13.
     
 0.648
LHFPL2
LHFPL tetraspan subfamily member 2.
      
 0.577
AP2M1
AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]
    
 0.574
MAGI2
Membrane associated guanylate kinase, WW and PDZ domain containing 2.
    
   0.561
AP2S1
AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.
   
  0.551
RND1
Rho family GTPase 1.
    
 0.534
Your Current Organism:
Mandrillus leucophaeus
NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill
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