STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SMYD4SET and MYND domain containing 4. (740 aa)    
Predicted Functional Partners:
DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific.
    
 0.800
TP53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
   
 0.785
KMT5A
Lysine methyltransferase 5A.
    
 0.759
CAMKMT
Calmodulin-lysine N-methyltransferase.
     
 0.749
LOC105540858
MYND-type domain-containing protein.
   
 
 0.647
EHMT1
Euchromatic histone lysine methyltransferase 1.
     
 0.631
EHMT2
Euchromatic histone lysine methyltransferase 2.
     
 0.631
ASH1L
ASH1 like histone lysine methyltransferase.
     
 0.618
SETD5
SET domain containing 5.
   
 0.606
PLOD2
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2.
   
  0.581
Your Current Organism:
Mandrillus leucophaeus
NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.