STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TWIST2Twist family bHLH transcription factor 2. (160 aa)    
Predicted Functional Partners:
CD44
CD44 molecule (Indian blood group).
     
 0.895
TCF12
Transcription factor 12.
    
 
 0.625
TCF3
BHLH domain-containing protein.
    
 
 0.594
LOC105534402
BHLH domain-containing protein.
    
 
 0.594
TCF4
Transcription factor 4.
    
 
 0.578
ZEB1
Zinc finger E-box binding homeobox 1.
     
 0.495
ZEB2
Zinc finger E-box binding homeobox 2.
     
 0.492
PKP1
Plakophilin 1.
      
 0.483
RELA
RELA proto-oncogene, NF-kB subunit.
   
 
 0.442
TP53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
   
 
 0.428
Your Current Organism:
Mandrillus leucophaeus
NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill
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