STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NSMCE4ANon-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. (300 aa)    
Predicted Functional Partners:
NSMCE1
NSE1 homolog, SMC5-SMC6 complex component.
   
 0.998
SMC6
Structural maintenance of chromosomes 6.
   
 0.998
SMC5
SMC_N domain-containing protein.
   
 0.998
NSMCE2
SP-RING-type domain-containing protein.
    
 0.981
LOC105544081
SP-RING-type domain-containing protein.
    
 0.981
SMC3
Structural maintenance of chromosomes protein.
   
 0.940
SMC1B
Structural maintenance of chromosomes protein.
   
 0.890
SMC1A
Structural maintenance of chromosomes protein.
   
 0.890
SMC4
Structural maintenance of chromosomes protein.
   
 0.886
SMC2
Structural maintenance of chromosomes protein.
   
 0.866
Your Current Organism:
Mandrillus leucophaeus
NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.