STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SELLL-selectin; Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia. (385 aa)    
Predicted Functional Partners:
CD34
CD34 molecule.
   
 
 0.952
MADCAM1
Adhes-Ig_like domain-containing protein.
    
 0.938
SELPLG
Selectin P ligand.
   
 0.925
CD44
CD44 molecule (Indian blood group).
   
 0.916
CCR7
C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.
   
  
 0.815
IL2RG
Fibronectin type-III domain-containing protein.
   
  
 0.727
CD69
CD69 molecule.
   
  
 0.723
IFNG
Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
   
  
 0.714
PTPRC
Protein tyrosine phosphatase receptor type C.
   
 0.694
LOC105551010
Ig-like domain-containing protein.
   
  
 0.692
Your Current Organism:
Mandrillus leucophaeus
NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.