STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TMPRSS4Transmembrane serine protease 4; Belongs to the peptidase S1 family. (435 aa)    
Predicted Functional Partners:
TMPRSS2
Transmembrane serine protease 2; Belongs to the peptidase S1 family.
  
0.939
FURIN
Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.
     
 0.622
ACE2
Angiotensin-converting enzyme.
   
  
 0.598
CTSL
Cathepsin L; Belongs to the peptidase C1 family.
     
 0.569
CTSS
Cathepsin S; Belongs to the peptidase C1 family.
     
 0.563
CTSB
Cathepsin B; Belongs to the peptidase C1 family.
     
 0.538
MET
MET proto-oncogene, receptor tyrosine kinase.
    
  0.537
MST1R
Macrophage stimulating 1 receptor.
    
  0.537
RAB14
RAB14, member RAS oncogene family.
    
 0.500
TOP3B
DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.
      
 0.489
Your Current Organism:
Mandrillus leucophaeus
NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.