| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| MED1 | NCOA1 | ENSMLEP00000028914 | ENSMLEP00000017206 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Nuclear receptor coactivator. | 0.754 |
| MED1 | NCOA2 | ENSMLEP00000028914 | ENSMLEP00000020494 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Nuclear receptor coactivator. | 0.650 |
| MED1 | NR1H2 | ENSMLEP00000028914 | ENSMLEP00000006449 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Nuclear receptor subfamily 1 group H member 2. | 0.801 |
| MED1 | NR1H3 | ENSMLEP00000028914 | ENSMLEP00000040510 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Nuclear receptor subfamily 1 group H member 3. | 0.801 |
| MED1 | NR1H4 | ENSMLEP00000028914 | ENSMLEP00000006139 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Nuclear receptor subfamily 1 group H member 4. | 0.861 |
| MED1 | PPARA | ENSMLEP00000028914 | ENSMLEP00000021307 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Peroxisome proliferator activated receptor alpha. | 0.925 |
| MED1 | PPARG | ENSMLEP00000028914 | ENSMLEP00000038827 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.974 |
| MED1 | RARA | ENSMLEP00000028914 | ENSMLEP00000036591 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Retinoic acid receptor alpha. | 0.808 |
| MED1 | RARB | ENSMLEP00000028914 | ENSMLEP00000021263 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Retinoic acid receptor beta. | 0.904 |
| MED1 | RXRA | ENSMLEP00000028914 | ENSMLEP00000009755 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Retinoid X receptor alpha. | 0.976 |
| NCOA1 | MED1 | ENSMLEP00000017206 | ENSMLEP00000028914 | Nuclear receptor coactivator. | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | 0.754 |
| NCOA1 | NCOA2 | ENSMLEP00000017206 | ENSMLEP00000020494 | Nuclear receptor coactivator. | Nuclear receptor coactivator. | 0.975 |
| NCOA1 | NR1H2 | ENSMLEP00000017206 | ENSMLEP00000006449 | Nuclear receptor coactivator. | Nuclear receptor subfamily 1 group H member 2. | 0.927 |
| NCOA1 | NR1H3 | ENSMLEP00000017206 | ENSMLEP00000040510 | Nuclear receptor coactivator. | Nuclear receptor subfamily 1 group H member 3. | 0.943 |
| NCOA1 | NR1H4 | ENSMLEP00000017206 | ENSMLEP00000006139 | Nuclear receptor coactivator. | Nuclear receptor subfamily 1 group H member 4. | 0.952 |
| NCOA1 | PPARA | ENSMLEP00000017206 | ENSMLEP00000021307 | Nuclear receptor coactivator. | Peroxisome proliferator activated receptor alpha. | 0.956 |
| NCOA1 | PPARG | ENSMLEP00000017206 | ENSMLEP00000038827 | Nuclear receptor coactivator. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.961 |
| NCOA1 | RARA | ENSMLEP00000017206 | ENSMLEP00000036591 | Nuclear receptor coactivator. | Retinoic acid receptor alpha. | 0.927 |
| NCOA1 | RARB | ENSMLEP00000017206 | ENSMLEP00000021263 | Nuclear receptor coactivator. | Retinoic acid receptor beta. | 0.918 |
| NCOA1 | RXRA | ENSMLEP00000017206 | ENSMLEP00000009755 | Nuclear receptor coactivator. | Retinoid X receptor alpha. | 0.983 |