node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ENSMLEP00000012889 | FPGS | ENSMLEP00000012889 | ENSMLEP00000005449 | Nudix hydrolase domain-containing protein. | Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. | 0.886 |
ENSMLEP00000012889 | GCH1 | ENSMLEP00000012889 | ENSMLEP00000033174 | Nudix hydrolase domain-containing protein. | GTP cyclohydrolase 1. | 0.908 |
ENSMLEP00000012889 | GLDC | ENSMLEP00000012889 | ENSMLEP00000039469 | Nudix hydrolase domain-containing protein. | Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.806 |
ENSMLEP00000012889 | MROH6 | ENSMLEP00000012889 | ENSMLEP00000018214 | Nudix hydrolase domain-containing protein. | Maestro heat like repeat family member 6. | 0.782 |
ENSMLEP00000012889 | NADSYN1 | ENSMLEP00000012889 | ENSMLEP00000040860 | Nudix hydrolase domain-containing protein. | Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family. | 0.909 |
ENSMLEP00000012889 | NAPRT | ENSMLEP00000012889 | ENSMLEP00000031310 | Nudix hydrolase domain-containing protein. | Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. | 0.782 |
ENSMLEP00000012889 | NT5E | ENSMLEP00000012889 | ENSMLEP00000038771 | Nudix hydrolase domain-containing protein. | 5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family. | 0.817 |
ENSMLEP00000012889 | QPRT | ENSMLEP00000012889 | ENSMLEP00000025756 | Nudix hydrolase domain-containing protein. | Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. | 0.886 |
ENSMLEP00000012889 | RRM1 | ENSMLEP00000012889 | ENSMLEP00000037579 | Nudix hydrolase domain-containing protein. | Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.840 |
ENSMLEP00000012889 | TYMS | ENSMLEP00000012889 | ENSMLEP00000017773 | Nudix hydrolase domain-containing protein. | Thymidylate synthetase. | 0.869 |
FPGS | ENSMLEP00000012889 | ENSMLEP00000005449 | ENSMLEP00000012889 | Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. | Nudix hydrolase domain-containing protein. | 0.886 |
FPGS | GCH1 | ENSMLEP00000005449 | ENSMLEP00000033174 | Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. | GTP cyclohydrolase 1. | 0.846 |
FPGS | GLDC | ENSMLEP00000005449 | ENSMLEP00000039469 | Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. | Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.513 |
FPGS | NADSYN1 | ENSMLEP00000005449 | ENSMLEP00000040860 | Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. | Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family. | 0.523 |
FPGS | TYMS | ENSMLEP00000005449 | ENSMLEP00000017773 | Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. | Thymidylate synthetase. | 0.929 |
GCH1 | ENSMLEP00000012889 | ENSMLEP00000033174 | ENSMLEP00000012889 | GTP cyclohydrolase 1. | Nudix hydrolase domain-containing protein. | 0.908 |
GCH1 | FPGS | ENSMLEP00000033174 | ENSMLEP00000005449 | GTP cyclohydrolase 1. | Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. | 0.846 |
GCH1 | NADSYN1 | ENSMLEP00000033174 | ENSMLEP00000040860 | GTP cyclohydrolase 1. | Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family. | 0.556 |
GCH1 | QPRT | ENSMLEP00000033174 | ENSMLEP00000025756 | GTP cyclohydrolase 1. | Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. | 0.474 |
GCH1 | RRM1 | ENSMLEP00000033174 | ENSMLEP00000037579 | GTP cyclohydrolase 1. | Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.764 |