RAB4B protein (Gorilla gorilla) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

RAB4B

Uncharacterized protein. (214 aa)

Predicted Functional Partners:

ITSN2

0.823

RBSN

0.729

ITSN1

0.687

ENSGGOP00000032065

0.665

TBC1D16

0.651

MST1R

0.640

MET

0.640

G3QLX7_GORGO

0.594

RABGGTB

0.586

GDI1

0.567

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSGGOP00000032065	MET	ENSGGOP00000032065	ENSGGOP00000041736	Uncharacterized protein.	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	0.645
ENSGGOP00000032065	MST1R	ENSGGOP00000032065	ENSGGOP00000011976	Uncharacterized protein.	Macrophage stimulating 1 receptor.	0.645
ENSGGOP00000032065	RAB4B	ENSGGOP00000032065	ENSGGOP00000031418	Uncharacterized protein.	Uncharacterized protein.	0.665
G3QLX7_GORGO	RAB4B	ENSGGOP00000003501	ENSGGOP00000031418	RUN domain-containing protein.	Uncharacterized protein.	0.594
GDI1	RAB4B	ENSGGOP00000013144	ENSGGOP00000031418	Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family.	Uncharacterized protein.	0.567
GDI1	RABGGTB	ENSGGOP00000013144	ENSGGOP00000004582	Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family.	Geranylgeranyl transferase type-2 subunit beta; Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C- terminal sequence -XXCC, -XCXC and -CCXX.	0.637
ITSN1	ITSN2	ENSGGOP00000034704	ENSGGOP00000007432	Intersectin 1.	Intersectin 2.	0.906
ITSN1	RAB4B	ENSGGOP00000034704	ENSGGOP00000031418	Intersectin 1.	Uncharacterized protein.	0.687
ITSN2	ITSN1	ENSGGOP00000007432	ENSGGOP00000034704	Intersectin 2.	Intersectin 1.	0.906
ITSN2	MET	ENSGGOP00000007432	ENSGGOP00000041736	Intersectin 2.	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	0.657
ITSN2	MST1R	ENSGGOP00000007432	ENSGGOP00000011976	Intersectin 2.	Macrophage stimulating 1 receptor.	0.657
ITSN2	RAB4B	ENSGGOP00000007432	ENSGGOP00000031418	Intersectin 2.	Uncharacterized protein.	0.823
MET	ENSGGOP00000032065	ENSGGOP00000041736	ENSGGOP00000032065	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	Uncharacterized protein.	0.645
MET	ITSN2	ENSGGOP00000041736	ENSGGOP00000007432	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	Intersectin 2.	0.657
MET	MST1R	ENSGGOP00000041736	ENSGGOP00000011976	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	Macrophage stimulating 1 receptor.	0.740
MET	RAB4B	ENSGGOP00000041736	ENSGGOP00000031418	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	Uncharacterized protein.	0.640
MST1R	ENSGGOP00000032065	ENSGGOP00000011976	ENSGGOP00000032065	Macrophage stimulating 1 receptor.	Uncharacterized protein.	0.645
MST1R	ITSN2	ENSGGOP00000011976	ENSGGOP00000007432	Macrophage stimulating 1 receptor.	Intersectin 2.	0.657
MST1R	MET	ENSGGOP00000011976	ENSGGOP00000041736	Macrophage stimulating 1 receptor.	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	0.740
MST1R	RAB4B	ENSGGOP00000011976	ENSGGOP00000031418	Macrophage stimulating 1 receptor.	Uncharacterized protein.	0.640