Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
XPAXPA, DNA damage recognition and repair factor. (273 aa)    
Predicted Functional Partners:
ERCC1
ERCC excision repair 1, endonuclease non-catalytic subunit.
    
 0.999
ERCC4
ERCC excision repair 4, endonuclease catalytic subunit.
    
 0.998
ERCC3
ERCC excision repair 3, TFIIH core complex helicase subunit.
    
 0.992
RPA1
Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.
    
 0.983
RPA3
Replication protein A3.
    
 0.983
RAD23B
RAD23 homolog B, nucleotide excision repair protein.
    
 0.981
XPC
XPC complex subunit, DNA damage recognition and repair factor.
    
 0.980
SLU7
SLU7 homolog, splicing factor.
   
  
 0.978
ERCC5
BIVM-ERCC5 readthrough.
    
 0.976
ERCC2
ERCC excision repair 2, TFIIH core complex helicase subunit.
    
 0.974
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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