MVK protein (Gorilla gorilla) - STRING interaction network

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MVK

Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (396 aa)

Predicted Functional Partners:

HMGCR

0.995

MVD

0.993

PMVK

0.979

CTH

0.901

HMGCL

0.854

HMGCLL1

0.854

ACAT1

0.773

HMGCS1

0.753

ACAT2

0.744

G3QF02_GORGO

0.698

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACAT1	HMGCL	ENSGGOP00000012332	ENSGGOP00000004258	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	3-hydroxy-3-methylglutaryl-CoA lyase.	0.574
ACAT1	HMGCLL1	ENSGGOP00000012332	ENSGGOP00000048979	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Pyruvate carboxyltransferase domain-containing protein.	0.436
ACAT1	HMGCR	ENSGGOP00000012332	ENSGGOP00000046002	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.547
ACAT1	HMGCS1	ENSGGOP00000012332	ENSGGOP00000001124	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.942
ACAT1	MVD	ENSGGOP00000012332	ENSGGOP00000012243	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes.	0.696
ACAT1	MVK	ENSGGOP00000012332	ENSGGOP00000050965	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	0.773
ACAT1	PMVK	ENSGGOP00000012332	ENSGGOP00000012523	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Phosphomevalonate kinase.	0.554
ACAT2	HMGCL	ENSGGOP00000013709	ENSGGOP00000004258	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	3-hydroxy-3-methylglutaryl-CoA lyase.	0.938
ACAT2	HMGCLL1	ENSGGOP00000013709	ENSGGOP00000048979	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	Pyruvate carboxyltransferase domain-containing protein.	0.938
ACAT2	HMGCR	ENSGGOP00000013709	ENSGGOP00000046002	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.679
ACAT2	HMGCS1	ENSGGOP00000013709	ENSGGOP00000001124	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.993
ACAT2	MVD	ENSGGOP00000013709	ENSGGOP00000012243	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes.	0.688
ACAT2	MVK	ENSGGOP00000013709	ENSGGOP00000050965	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	0.744
ACAT2	PMVK	ENSGGOP00000013709	ENSGGOP00000012523	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	Phosphomevalonate kinase.	0.517
CTH	MVK	ENSGGOP00000016141	ENSGGOP00000050965	Cystathionine gamma-lyase.	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	0.901
G3QF02_GORGO	MVK	ENSGGOP00000037337	ENSGGOP00000050965	SH3 and SYLF domain containing 1.	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	0.698
HMGCL	ACAT1	ENSGGOP00000004258	ENSGGOP00000012332	3-hydroxy-3-methylglutaryl-CoA lyase.	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	0.574
HMGCL	ACAT2	ENSGGOP00000004258	ENSGGOP00000013709	3-hydroxy-3-methylglutaryl-CoA lyase.	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	0.938
HMGCL	HMGCLL1	ENSGGOP00000004258	ENSGGOP00000048979	3-hydroxy-3-methylglutaryl-CoA lyase.	Pyruvate carboxyltransferase domain-containing protein.	0.912
HMGCL	HMGCR	ENSGGOP00000004258	ENSGGOP00000046002	3-hydroxy-3-methylglutaryl-CoA lyase.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.840

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