| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CDK4 | GADD45A | ENSGGOP00000001387 | ENSGGOP00000010511 | Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. | Growth arrest and DNA damage inducible alpha. | 0.488 |
| CDK4 | LIG1 | ENSGGOP00000001387 | ENSGGOP00000014693 | Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. | DNA ligase. | 0.407 |
| CDK4 | PCNA | ENSGGOP00000001387 | ENSGGOP00000001670 | Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.995 |
| CDK4 | POLE | ENSGGOP00000001387 | ENSGGOP00000009788 | Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. | 0.590 |
| CDK4 | RFC4 | ENSGGOP00000001387 | ENSGGOP00000031024 | Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. | Replication factor C subunit 4. | 0.461 |
| FEN1 | LIG1 | ENSGGOP00000012253 | ENSGGOP00000014693 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | DNA ligase. | 0.947 |
| FEN1 | PCNA | ENSGGOP00000012253 | ENSGGOP00000001670 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.992 |
| FEN1 | POLE | ENSGGOP00000012253 | ENSGGOP00000009788 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. | 0.817 |
| FEN1 | RFC2 | ENSGGOP00000012253 | ENSGGOP00000042861 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Replication factor C subunit 2. | 0.863 |
| FEN1 | RFC3 | ENSGGOP00000012253 | ENSGGOP00000016778 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Replication factor C subunit 3. | 0.892 |
| FEN1 | RFC4 | ENSGGOP00000012253 | ENSGGOP00000031024 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Replication factor C subunit 4. | 0.896 |
| FEN1 | RFC5 | ENSGGOP00000012253 | ENSGGOP00000002536 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Replication factor C subunit 5. | 0.798 |
| GADD45A | CDK4 | ENSGGOP00000010511 | ENSGGOP00000001387 | Growth arrest and DNA damage inducible alpha. | Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. | 0.488 |
| GADD45A | PCNA | ENSGGOP00000010511 | ENSGGOP00000001670 | Growth arrest and DNA damage inducible alpha. | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.997 |
| LIG1 | CDK4 | ENSGGOP00000014693 | ENSGGOP00000001387 | DNA ligase. | Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. | 0.407 |
| LIG1 | FEN1 | ENSGGOP00000014693 | ENSGGOP00000012253 | DNA ligase. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.947 |
| LIG1 | PCNA | ENSGGOP00000014693 | ENSGGOP00000001670 | DNA ligase. | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.993 |
| LIG1 | POLE | ENSGGOP00000014693 | ENSGGOP00000009788 | DNA ligase. | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. | 0.917 |
| LIG1 | RFC2 | ENSGGOP00000014693 | ENSGGOP00000042861 | DNA ligase. | Replication factor C subunit 2. | 0.843 |
| LIG1 | RFC3 | ENSGGOP00000014693 | ENSGGOP00000016778 | DNA ligase. | Replication factor C subunit 3. | 0.907 |
