Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
HRNREF-hand domain-containing protein. (2145 aa)    
Predicted Functional Partners:
CASP14
Caspase 14; Belongs to the peptidase C14A family.
   
 0.844
DSG1
Desmoglein 1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
   
 0.743
EVPL
Envoplakin.
   
 0.646
IVL
Involucrin_N domain-containing protein.
    
 0.638
S100A14
S100 calcium binding protein A14; Belongs to the S-100 family.
   
 
 0.615
TGM1
Transglutaminase 1.
   
 0.595
DSC1
Desmocollin 1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
   
 0.593
ANXA1
Annexin.
   
 0.592
ANLN
Anillin actin binding protein.
    
  0.586
KRT1
Keratin 1; Belongs to the intermediate filament family.
   
 0.575
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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