GLI3 protein (Gorilla gorilla) - STRING interaction network

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[Homology]

Score

GLI3

GLI family zinc finger 3. (1580 aa)

Predicted Functional Partners:

ENSGGOP00000036799

0.999

G3R1K3_GORGO

0.996

GLI1

0.986

SPOPL

0.984

GLI2

0.983

BTRC

0.982

PRKACB

0.977

ENSGGOP00000032040

0.977

KIF7

0.974

CUL3

0.972

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BTRC	CUL3	ENSGGOP00000020770	ENSGGOP00000007292	Beta-transducin repeat containing E3 ubiquitin protein ligase.	Cullin 3; Belongs to the cullin family.	0.816
BTRC	ENSGGOP00000036799	ENSGGOP00000020770	ENSGGOP00000036799	Beta-transducin repeat containing E3 ubiquitin protein ligase.	Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...]	0.518
BTRC	GLI1	ENSGGOP00000020770	ENSGGOP00000038126	Beta-transducin repeat containing E3 ubiquitin protein ligase.	GLI family zinc finger 1.	0.981
BTRC	GLI2	ENSGGOP00000020770	ENSGGOP00000009432	Beta-transducin repeat containing E3 ubiquitin protein ligase.	GLI family zinc finger 2.	0.972
BTRC	GLI3	ENSGGOP00000020770	ENSGGOP00000002001	Beta-transducin repeat containing E3 ubiquitin protein ligase.	GLI family zinc finger 3.	0.982
CUL3	BTRC	ENSGGOP00000007292	ENSGGOP00000020770	Cullin 3; Belongs to the cullin family.	Beta-transducin repeat containing E3 ubiquitin protein ligase.	0.816
CUL3	ENSGGOP00000036799	ENSGGOP00000007292	ENSGGOP00000036799	Cullin 3; Belongs to the cullin family.	Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...]	0.954
CUL3	G3R1K3_GORGO	ENSGGOP00000007292	ENSGGOP00000009080	Cullin 3; Belongs to the cullin family.	BTB domain-containing protein.	0.998
CUL3	GLI1	ENSGGOP00000007292	ENSGGOP00000038126	Cullin 3; Belongs to the cullin family.	GLI family zinc finger 1.	0.957
CUL3	GLI2	ENSGGOP00000007292	ENSGGOP00000009432	Cullin 3; Belongs to the cullin family.	GLI family zinc finger 2.	0.971
CUL3	GLI3	ENSGGOP00000007292	ENSGGOP00000002001	Cullin 3; Belongs to the cullin family.	GLI family zinc finger 3.	0.972
CUL3	SPOPL	ENSGGOP00000007292	ENSGGOP00000028136	Cullin 3; Belongs to the cullin family.	Speckle type BTB/POZ protein like.	0.992
ENSGGOP00000032040	ENSGGOP00000036799	ENSGGOP00000032040	ENSGGOP00000036799	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily.	Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...]	0.754
ENSGGOP00000032040	GLI1	ENSGGOP00000032040	ENSGGOP00000038126	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily.	GLI family zinc finger 1.	0.964
ENSGGOP00000032040	GLI2	ENSGGOP00000032040	ENSGGOP00000009432	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily.	GLI family zinc finger 2.	0.966
ENSGGOP00000032040	GLI3	ENSGGOP00000032040	ENSGGOP00000002001	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily.	GLI family zinc finger 3.	0.977
ENSGGOP00000032040	KIF7	ENSGGOP00000032040	ENSGGOP00000008323	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily.	Kinesin family member 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.600
ENSGGOP00000032040	PRKACB	ENSGGOP00000032040	ENSGGOP00000025699	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.999
ENSGGOP00000036799	BTRC	ENSGGOP00000036799	ENSGGOP00000020770	Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...]	Beta-transducin repeat containing E3 ubiquitin protein ligase.	0.518
ENSGGOP00000036799	CUL3	ENSGGOP00000036799	ENSGGOP00000007292	Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...]	Cullin 3; Belongs to the cullin family.	0.954