| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACLY | CS | ENSGGOP00000020058 | ENSGGOP00000022736 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | Citrate synthase; Belongs to the citrate synthase family. | 0.986 |
| ACLY | DLAT | ENSGGOP00000020058 | ENSGGOP00000002482 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.977 |
| ACLY | DLD | ENSGGOP00000020058 | ENSGGOP00000044357 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | Dihydrolipoyl dehydrogenase. | 0.652 |
| ACLY | PDHB | ENSGGOP00000020058 | ENSGGOP00000012827 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | 0.532 |
| ACLY | PDHX | ENSGGOP00000020058 | ENSGGOP00000001190 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. | 0.749 |
| ACLY | SUCLG1 | ENSGGOP00000020058 | ENSGGOP00000002006 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. | 0.920 |
| CS | ACLY | ENSGGOP00000022736 | ENSGGOP00000020058 | Citrate synthase; Belongs to the citrate synthase family. | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | 0.986 |
| CS | DLAT | ENSGGOP00000022736 | ENSGGOP00000002482 | Citrate synthase; Belongs to the citrate synthase family. | Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.988 |
| CS | DLD | ENSGGOP00000022736 | ENSGGOP00000044357 | Citrate synthase; Belongs to the citrate synthase family. | Dihydrolipoyl dehydrogenase. | 0.842 |
| CS | G3RRJ9_GORGO | ENSGGOP00000022736 | ENSGGOP00000018423 | Citrate synthase; Belongs to the citrate synthase family. | Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.668 |
| CS | PDHA1 | ENSGGOP00000022736 | ENSGGOP00000033725 | Citrate synthase; Belongs to the citrate synthase family. | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial isoform X1. | 0.668 |
| CS | PDHA2 | ENSGGOP00000022736 | ENSGGOP00000013411 | Citrate synthase; Belongs to the citrate synthase family. | Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.668 |
| CS | PDHB | ENSGGOP00000022736 | ENSGGOP00000012827 | Citrate synthase; Belongs to the citrate synthase family. | Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | 0.807 |
| CS | PDHX | ENSGGOP00000022736 | ENSGGOP00000001190 | Citrate synthase; Belongs to the citrate synthase family. | Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. | 0.829 |
| CS | SUCLG1 | ENSGGOP00000022736 | ENSGGOP00000002006 | Citrate synthase; Belongs to the citrate synthase family. | Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. | 0.869 |
| DLAT | ACLY | ENSGGOP00000002482 | ENSGGOP00000020058 | Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | 0.977 |
| DLAT | CS | ENSGGOP00000002482 | ENSGGOP00000022736 | Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Citrate synthase; Belongs to the citrate synthase family. | 0.988 |
| DLAT | DLD | ENSGGOP00000002482 | ENSGGOP00000044357 | Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Dihydrolipoyl dehydrogenase. | 0.999 |
| DLAT | G3RRJ9_GORGO | ENSGGOP00000002482 | ENSGGOP00000018423 | Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.999 |
| DLAT | LIPT1 | ENSGGOP00000002482 | ENSGGOP00000021620 | Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Lipoyltransferase 1. | 0.984 |
