SREBF1 protein (Gorilla gorilla) - STRING interaction network

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Score

SREBF1

Sterol regulatory element binding transcription factor 1. (1177 aa)

Predicted Functional Partners:

PPARGC1B

0.966

SCAP

0.913

ENSGGOP00000045173

0.913

SREBF2

0.908

EP300

0.903

SCD

0.873

FBXW7

0.871

PPARG

0.866

MED15

0.865

ACACA

0.864

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACACA	PPARG	ENSGGOP00000016675	ENSGGOP00000032598	Acetyl-CoA carboxylase alpha.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.523
ACACA	SCD	ENSGGOP00000016675	ENSGGOP00000001081	Acetyl-CoA carboxylase alpha.	Stearoyl-CoA desaturase; Belongs to the fatty acid desaturase type 1 family.	0.776
ACACA	SREBF1	ENSGGOP00000016675	ENSGGOP00000050798	Acetyl-CoA carboxylase alpha.	Sterol regulatory element binding transcription factor 1.	0.864
ACACA	SREBF2	ENSGGOP00000016675	ENSGGOP00000011780	Acetyl-CoA carboxylase alpha.	Sterol regulatory element binding transcription factor 2.	0.558
ENSGGOP00000045173	SCAP	ENSGGOP00000045173	ENSGGOP00000037185	Uncharacterized protein.	SSD domain-containing protein.	0.951
ENSGGOP00000045173	SREBF1	ENSGGOP00000045173	ENSGGOP00000050798	Uncharacterized protein.	Sterol regulatory element binding transcription factor 1.	0.913
ENSGGOP00000045173	SREBF2	ENSGGOP00000045173	ENSGGOP00000011780	Uncharacterized protein.	Sterol regulatory element binding transcription factor 2.	0.921
EP300	FBXW7	ENSGGOP00000008032	ENSGGOP00000026487	E1A binding protein p300.	F-box and WD repeat domain containing 7.	0.514
EP300	MED15	ENSGGOP00000008032	ENSGGOP00000021420	E1A binding protein p300.	Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.522
EP300	PPARG	ENSGGOP00000008032	ENSGGOP00000032598	E1A binding protein p300.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.975
EP300	SREBF1	ENSGGOP00000008032	ENSGGOP00000050798	E1A binding protein p300.	Sterol regulatory element binding transcription factor 1.	0.903
EP300	SREBF2	ENSGGOP00000008032	ENSGGOP00000011780	E1A binding protein p300.	Sterol regulatory element binding transcription factor 2.	0.555
FBXW7	EP300	ENSGGOP00000026487	ENSGGOP00000008032	F-box and WD repeat domain containing 7.	E1A binding protein p300.	0.514
FBXW7	SREBF1	ENSGGOP00000026487	ENSGGOP00000050798	F-box and WD repeat domain containing 7.	Sterol regulatory element binding transcription factor 1.	0.871
FBXW7	SREBF2	ENSGGOP00000026487	ENSGGOP00000011780	F-box and WD repeat domain containing 7.	Sterol regulatory element binding transcription factor 2.	0.455
MED15	EP300	ENSGGOP00000021420	ENSGGOP00000008032	Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	E1A binding protein p300.	0.522
MED15	PPARGC1B	ENSGGOP00000021420	ENSGGOP00000009290	Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	PPARG coactivator 1 beta.	0.567
MED15	SREBF1	ENSGGOP00000021420	ENSGGOP00000050798	Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Sterol regulatory element binding transcription factor 1.	0.865
MED15	SREBF2	ENSGGOP00000021420	ENSGGOP00000011780	Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Sterol regulatory element binding transcription factor 2.	0.683
PPARG	ACACA	ENSGGOP00000032598	ENSGGOP00000016675	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	Acetyl-CoA carboxylase alpha.	0.523