| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BHMT | DMGDH | ENSGGOP00000007397 | ENSGGOP00000003151 | Betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. | Dimethylglycine dehydrogenase. | 0.976 |
| BHMT | MTHFD2 | ENSGGOP00000007397 | ENSGGOP00000044699 | Betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. | Uncharacterized protein. | 0.464 |
| BHMT | MTHFD2L | ENSGGOP00000007397 | ENSGGOP00000014952 | Betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. | Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like. | 0.464 |
| BHMT | MTHFR | ENSGGOP00000007397 | ENSGGOP00000030609 | Betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.886 |
| BHMT | MTR | ENSGGOP00000007397 | ENSGGOP00000015745 | Betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.945 |
| BHMT | PIPOX | ENSGGOP00000007397 | ENSGGOP00000012065 | Betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. | Pipecolic acid and sarcosine oxidase. | 0.591 |
| BHMT | SHMT1 | ENSGGOP00000007397 | ENSGGOP00000030416 | Betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. | 0.692 |
| BHMT | SHMT2 | ENSGGOP00000007397 | ENSGGOP00000009996 | Betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. | 0.590 |
| DHFR | DMGDH | ENSGGOP00000042696 | ENSGGOP00000003151 | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | Dimethylglycine dehydrogenase. | 0.968 |
| DHFR | G3R4K9_GORGO | ENSGGOP00000042696 | ENSGGOP00000010215 | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. | 0.968 |
| DHFR | MTHFR | ENSGGOP00000042696 | ENSGGOP00000030609 | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.576 |
| DHFR | MTR | ENSGGOP00000042696 | ENSGGOP00000015745 | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.946 |
| DHFR | PIPOX | ENSGGOP00000042696 | ENSGGOP00000012065 | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | Pipecolic acid and sarcosine oxidase. | 0.467 |
| DHFR | SHMT1 | ENSGGOP00000042696 | ENSGGOP00000030416 | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. | 0.983 |
| DHFR | SHMT2 | ENSGGOP00000042696 | ENSGGOP00000009996 | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. | 0.983 |
| DMGDH | BHMT | ENSGGOP00000003151 | ENSGGOP00000007397 | Dimethylglycine dehydrogenase. | Betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. | 0.976 |
| DMGDH | DHFR | ENSGGOP00000003151 | ENSGGOP00000042696 | Dimethylglycine dehydrogenase. | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | 0.968 |
| DMGDH | G3R4K9_GORGO | ENSGGOP00000003151 | ENSGGOP00000010215 | Dimethylglycine dehydrogenase. | Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. | 0.955 |
| DMGDH | MTHFD2 | ENSGGOP00000003151 | ENSGGOP00000044699 | Dimethylglycine dehydrogenase. | Uncharacterized protein. | 0.957 |
| DMGDH | MTHFD2L | ENSGGOP00000003151 | ENSGGOP00000014952 | Dimethylglycine dehydrogenase. | Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like. | 0.969 |
